Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 6/20 | 0.70 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.63 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.58 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 4/20 | 0.56 |
| ▸ | DRD3 | P35462 | 3/20 | 0.56 |
| ▸ | CTSS | P25774 | 2/20 | 0.56 |
| ▸ | HTR1A | P08908 | 2/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.56 |
| ▸ | HTR2A | P28223 | 2/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.56 |
| ▸ | DRD4 | P21917 | 2/20 | 0.55 |
| ▸ | AKT1 | P31749 | 1/20 | 0.54 |
| ▸ | AKT2 | P31751 | 1/20 | 0.54 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.54 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.54 |
| ▸ | GMNN | O75496 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10373792 | 0.94 | CHRM1 (0.64) | CHRM1OPRM1OPRK1OPRL1DRD2 | |
| SCHEMBL10373947 | 0.91 | CHRM1 (0.60) | CHRM1OPRM1DRD2DRD3CTSS | |
| SCHEMBL10372779 | 0.90 | OPRM1 (0.73) | CHRM1OPRM1OPRK1OPRL1AKT1 | |
| SCHEMBL10373206 | 0.90 | OPRM1 (0.69) | OPRM1OPRK1OPRL1DRD4AKT1 | |
| SCHEMBL10374306 | 0.89 | OPRM1 (0.61) | CHRM1OPRM1OPRK1OPRL1DRD2 | |
| SCHEMBL10373489 | 0.88 | OPRM1 (0.59) | CHRM1OPRM1DRD2DRD3CTSS | |
| SCHEMBL6161133 | 0.86 | CHRM1 (0.92) | CHRM1OPRM1OPRK1OPRL1DRD2 | |
| SCHEMBL10465105 | 0.84 | CHRM1 (0.66) | CHRM1OPRM1OPRK1OPRL1DRD2 | |
| SCHEMBL10373160 | 0.83 | OPRM1 (0.58) | CHRM1OPRM1OPRK1OPRL1DRD2 | |
| SCHEMBL10371706 | 0.83 | CHRM1 (0.66) | CHRM1OPRM1OPRK1DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4906642-A | Pyridine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-03-06 | — | — | US | disclosed |
| EP-0237908-A2 | Pyridine derivatives | MERCK PATENT GmbH (DE) | 1987-09-23 | — | — | EP | disclosed |