Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 6/20 | 0.92 |
| ▸ | OPRM1 | P35372 | 12/20 | 0.78 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.76 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.76 |
| ▸ | DRD2 | P14416 | 3/20 | 0.70 |
| ▸ | DRD3 | P35462 | 3/20 | 0.70 |
| ▸ | HTR1A | P08908 | 2/20 | 0.70 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.70 |
| ▸ | HTR2A | P28223 | 2/20 | 0.70 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.69 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.69 |
| ▸ | GMNN | O75496 | 1/20 | 0.69 |
| ▸ | USP2 | O75604 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
| ▸ | GLA | P06280 | 1/20 | 0.69 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.69 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6504138 | 0.91 | CHRM1 (0.77) | CHRM1OPRM1OPRK1OPRL1DRD2 | |
| SCHEMBL8884316 | 0.91 | OPRM1 (0.78) | CHRM1OPRM1OPRK1OPRL1DRD2 | |
| SCHEMBL6583079 | 0.87 | OPRM1 (0.77) | CHRM1OPRM1OPRK1OPRL1DRD2 | |
| SCHEMBL10374625 | 0.87 | CHRM1 (0.71) | CHRM1OPRM1OPRK1OPRL1DRD2 | |
| SCHEMBL3665096 | 0.87 | OPRM1 (1.00) | CHRM1OPRM1OPRK1OPRL1DRD2 | |
| SCHEMBL10465124 | 0.86 | CHRM1 (0.70) | CHRM1OPRM1OPRK1OPRL1DRD2 | |
| SCHEMBL11179730 | 0.84 | OPRM1 (0.72) | CHRM1OPRM1OPRK1OPRL1DRD2 | |
| SCHEMBL10465105 | 0.83 | CHRM1 (0.66) | CHRM1OPRM1OPRK1OPRL1DRD2 | |
| SCHEMBL10371706 | 0.83 | CHRM1 (0.66) | CHRM1OPRM1OPRK1DRD2DRD3 | |
| SCHEMBL10373509 | 0.82 | CHRM1 (0.65) | CHRM1OPRM1OPRK1OPRL1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10751335-B2 | Signaling-biased mu opioid receptor agonists | THE SCRIPPS RESEARCH INSTITUTE (US) | 2020-08-25 | — | — | US | disclosed |
| US-20190055214-A1 | SIGNALING-BIASED MU OPIOID RECEPTOR AGONISTS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED | 2019-02-21 | — | — | US | disclosed |
| EP-0828754-B1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER (US) | 2005-02-02 | — | — | EP | disclosed |
| US-5936089-A | PIPERIDINE DERIVATIVES; BONE DISORDERS; OBESITY; AGING; CACHEXIA ASSOCIATED WITH AIDS AND CANCER | PFIZER INC (US) | 1999-08-10 | — | — | US | disclosed |
| EP-0828754-A1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER INC. (US) | 1998-03-18 | — | — | EP | disclosed |
| WO-1996038471-A1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER INC. (US) | 1996-12-05 | — | — | WO | disclosed |
| WO-1996035713-A1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER, INC. (US) | 1996-11-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10751335-B2 | Signaling-biased mu opioid receptor agonists | OPRK1, OPRM1, OPRD1 | CHRM1 104/4885OPRM1 2/4885OPRK1 1/4885 |
| US-20190055214-A1 | SIGNALING-BIASED MU OPIOID RECEPTOR AGONISTS | OPRK1, OPRM1, OPRD1 | CHRM1 104/4885OPRM1 2/4885OPRK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.