Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | NR5A2 | O00482 | 1/20 | 0.38 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TYR | P14679 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23793643 | 0.80 | CA2 (0.46) | HSP90AA1CA2CA1ALOX5PTGS2 | |
| SCHEMBL10467416 | 0.78 | ALDH1A1 (0.52) | CA2CA1PTGS2GAAALDH1A1 | |
| SCHEMBL394716 | 0.78 | CA2 (0.45) | HSP90AA1CA2CA1ALOX5PTGS2 | |
| SCHEMBL11686726 | 0.77 | CA2 (0.43) | HSP90AA1CA2CA1ALOX5PTGS2 | |
| SCHEMBL10465414 | 0.76 | HSP90AA1 (0.40) | HSP90AA1CA2CA1ALOX5PTGS2 | |
| SCHEMBL35141 | 0.74 | CA2 (0.67) | HSP90AA1CA2CA1GAAALDH1A1 | |
| SCHEMBL18593372 | 0.74 | CYP1A2 (0.42) | HSP90AA1CA2CA1ALOX5PTGS2 | |
| SCHEMBL29416834 | 0.73 | CA2 (0.52) | HSP90AA1CA2CA1GAANR5A2 | |
| SCHEMBL247483 | 0.73 | CA2 (0.52) | HSP90AA1CA2CA1GAANR5A2 | |
| SCHEMBL27560100 | 0.72 | ALDH1A1 (0.46) | HSP90AA1CA2CA1ALOX5PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4933355-A | ALDOSE REDUCTASE INHIBITORS | SANKYO COMPANY LIMITED (JP) | 1990-06-12 | — | — | US | disclosed |
| EP-0337819-A1 | Thiazole derivatives, their preparation and their use in the treatment of diabetes complications | Sankyo Company Limited (JP) | 1989-10-18 | — | — | EP | disclosed |