Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.48 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | PHGDH | O43175 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | TDO2 | P48775 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10468257 | 0.91 | HPGD (0.48) | HPGDHRH3MGLLPHGDHNAMPT | |
| SCHEMBL10468250 | 0.80 | TP53 (0.59) | — | |
| SCHEMBL10470105 | 0.79 | HPGD (0.49) | HPGDHRH3MGLLPHGDHGAA | |
| SCHEMBL9694201 | 0.79 | HDAC6 (0.50) | SMN1; SMN2LMNA | |
| SCHEMBL23498232 | 0.78 | GAA (0.58) | HPGDHRH3PHGDHNAMPTGAA | |
| SCHEMBL9390726 | 0.76 | HDAC6 (0.56) | IDO1MAPT | |
| SCHEMBL10467889 | 0.74 | SMN1; SMN2 (0.59) | NAMPTSMN1; SMN2LMNA | |
| SCHEMBL13508711 | 0.73 | CYP11B1 (0.65) | GAASMN1; SMN2LMNA | |
| SCHEMBL15754906 | 0.72 | PHGDH (0.66) | HPGDPHGDHNAMPTSMN1; SMN2CYP3A4 | |
| SCHEMBL27441902 | 0.72 | LTA4H (0.46) | SMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4804658-A | PLATELET-ACTIVATING FACTOR ANTAGONISTS | G. D. SEARLE & CO. (US) | 1989-02-14 | — | — | US | claimed |
| EP-0260613-A2 | Imidazopyridine derivatives, their preparation and their use as PAF-antagonists | G.D. Searle & Co. (US) | 1988-03-23 | — | — | EP | claimed |
| US-4962106-A | Treating platelet activating factor mediated disorders | G. D. SEARLE & CO. (US) | 1990-10-09 | — | — | US | disclosed |
| US-4804658-A | PLATELET-ACTIVATING FACTOR ANTAGONISTS | G. D. SEARLE & CO. (US) | 1989-02-14 | — | — | US | disclosed |
| EP-0260613-A2 | Imidazopyridine derivatives, their preparation and their use as PAF-antagonists | G.D. Searle & Co. (US) | 1988-03-23 | — | — | EP | disclosed |