Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 10/20 | 0.70 |
| ▸ | PDE3B | Q13370 | 9/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.38 |
| ▸ | PDE4A | P27815 | 2/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7377189 | 0.82 | PDE3B (1.00) | PDE3APDE3BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10554320 | 0.74 | PDE3B (0.46) | PDE3APDE3BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10690916 | 0.72 | PDE3B (0.46) | PDE3APDE3BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10551860 | 0.72 | PDE3B (0.46) | PDE3APDE3BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10468427 | 0.72 | PDE3B (0.69) | PDE3APDE3BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10469492 | 0.71 | PDE3B (0.71) | PDE3APDE3BPDE4BPDE4APDE4C | |
| SCHEMBL10550384 | 0.70 | PDE3B (0.46) | PDE3APDE3BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10684945 | 0.70 | PDE3B (0.44) | PDE3APDE3BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10553489 | 0.69 | PDE3B (0.69) | PDE3APDE3BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7383999 | 0.68 | PDE3B (1.00) | PDE3APDE3BCYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4954494-A | Cardiotonic and inotropic agents | RORER PHARMACEUTICAL CORPORATION (US) | 1990-09-04 | — | — | US | claimed |