Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 11/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 11/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.46 |
| ▸ | PDE4A | P27815 | 2/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10468427 | 0.80 | PDE3B (0.69) | PDE3BPDE3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10684945 | 0.78 | PDE3B (0.44) | PDE3BPDE3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10554320 | 0.78 | PDE3B (0.46) | PDE3BPDE3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10469492 | 0.76 | PDE3B (0.71) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10550384 | 0.73 | PDE3B (0.46) | PDE3BPDE3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10468163 | 0.72 | PDE3A (0.70) | PDE3BPDE3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10631471 | 0.71 | KMT2A (0.40) | PDE3BPDE3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10690916 | 0.71 | PDE3B (0.46) | PDE3BPDE3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10553489 | 0.70 | PDE3B (0.69) | PDE3BPDE3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10469541 | 0.69 | PDE3B (0.52) | PDE3BPDE3ACYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4847251-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-07-11 | — | — | US | disclosed |