Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.69 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | PDE2A | O00408 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | ADH5 | P11766 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7280366 | 0.82 | PDE3B (1.00) | PDE3BPDE3ALMNAKMT2APDE2A | |
| SCHEMBL7276956 | 0.81 | PDE3B (0.59) | PDE3BPDE3ALMNAKMT2APIM1 | |
| SCHEMBL10551346 | 0.79 | PDE3B (0.70) | PDE3BPDE3ALMNAPIM1PDE2A | |
| SCHEMBL12596036 | 0.75 | PDE3B (0.64) | PDE3BPDE3ALMNAKMT2APDE2A | |
| SCHEMBL7287713 | 0.75 | PDE3B (0.71) | PDE3BPDE3AKMT2APDE2AMEN1 | |
| SCHEMBL12648802 | 0.73 | PDE3B (0.60) | PDE3BPDE3ALMNAKMT2APDE2A | |
| SCHEMBL10648271 | 0.71 | PDE3A (0.59) | PDE3BPDE3ALMNAKMT2APDE2A | |
| SCHEMBL7280421 | 0.70 | PDE3B (0.61) | PDE3BPDE3A | |
| SCHEMBL10468427 | 0.70 | PDE3B (0.69) | PDE3BPDE3ALMNAPDE2ACYP1A2 | |
| SCHEMBL10551860 | 0.70 | PDE3B (0.46) | PDE3BPDE3ALMNAKMT2APIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4847251-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-07-11 | — | — | US | disclosed |
| EP-0255704-A2 | Pyridazinone derivatives, process for their preparation and their use as medicines | Roche Diagnostics GmbH (DE) | 1988-02-10 | — | — | EP | disclosed |