Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9173108 | 0.86 | CA1 (0.45) | SMN1; SMN2POLBALDH1A1RAB9AALOX15 | |
| SCHEMBL14341655 | 0.82 | SMN1; SMN2 (0.61) | SMN1; SMN2POLBALDH1A1RAB9AALOX15 | |
| SCHEMBL8953609 | 0.82 | CA1 (0.42) | SMN1; SMN2POLBALDH1A1RAB9AHSD17B10 | |
| SCHEMBL8430102 | 0.82 | SMN1; SMN2 (0.50) | SMN1; SMN2POLBALDH1A1RAB9AALOX15 | |
| SCHEMBL8953650 | 0.82 | SMN1; SMN2 (0.50) | SMN1; SMN2POLBALDH1A1RAB9AALOX15 | |
| SCHEMBL9706241 | 0.81 | EGFR (0.58) | SMN1; SMN2ALDH1A1CA1CA2HTT | |
| SCHEMBL8953767 | 0.80 | SMN1; SMN2 (0.49) | SMN1; SMN2POLBALDH1A1RAB9AALOX15 | |
| SCHEMBL27911758 | 0.80 | SMN1; SMN2 (0.49) | SMN1; SMN2POLBALDH1A1RAB9AALOX15 | |
| SCHEMBL9705596 | 0.79 | MLYCD (0.40) | SMN1; SMN2POLBALDH1A1RAB9AMAPT | |
| SCHEMBL7540622 | 0.79 | ROCK2 (0.48) | SMN1; SMN2POLBALDH1A1RAB9AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4940719-A | Tetrahydrocarbazole esters, pharmaceutical compositions and use | MERCK FROSST CANADA, INC. (CA) | 1990-07-10 | — | — | US | disclosed |
| EP-0310179-A2 | Tetrahydrocarbazole esters | MERCK FROSST CANADA INC. (CA) | 1989-04-05 | — | — | EP | disclosed |
| EP-0307077-A1 | Tetrahydrocarbazoles for the improvement of cyclosporin therapy | MERCK FROSST CANADA INC. (CA) | 1989-03-15 | — | — | EP | disclosed |
| US-4808608-A | ANTIALLERGENS, HYPOTENSIVE AGENT, ANTICOAGULANT | MERCK & CO., INC. (US) | 1989-02-28 | — | — | US | disclosed |
| EP-0300676-A2 | Tetrahydrocarbazole 1-alkanoic acids | MERCK FROSST CANADA INC. (CA) | 1989-01-25 | — | — | EP | disclosed |