Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3960185 | 0.86 | ALDH1A1 (0.51) | ALDH1A1KMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5029628 | 0.77 | PTPN1 (0.56) | PTPN1KMT2AMEN1NPC1RAB9A | |
| SCHEMBL3954390 | 0.76 | KMT2A (0.48) | ALDH1A1KMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6221281 | 0.75 | PTPN1 (0.67) | PTPN1ALDH1A1CYP2C19SMN1; SMN2HPGD | |
| SCHEMBL10489819 | 0.75 | KMT2A (0.63) | ALDH1A1KMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL10489832 | 0.74 | CYP1A2 (0.71) | ALDH1A1KMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL27564249 | 0.74 | SMN1; SMN2 (0.55) | ALDH1A1KMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL4607222 | 0.74 | KMT2A (0.46) | ALDH1A1KMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL11520630 | 0.73 | KDM4E (0.55) | ALDH1A1CYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL2845224 | 0.72 | CYP1A2 (0.54) | ALDH1A1KMT2ACYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4939137-A | Ring-fused thienopyrimidinedione derivatives | ORTHO PHARMACEUTICAL CORPORATION (US) | 1990-07-03 | — | — | US | disclosed |