SCHEMBL10470489

SCHEMBL10470489

CCCC1C(=O)Nc2cc([N+](=O)[O-])c(N)cc21

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 8/20 0.40
CYP1A2 P05177 2/20 0.38
CYP2C9 P11712 2/20 0.38
CYP2C19 P33261 2/20 0.38
ALDH1A1 P00352 3/20 0.36
LMNA P02545 1/20 0.36
TSHR P16473 2/20 0.35
IDO1 P14902 1/20 0.35
TDP1 Q9NUW8 5/20 0.33
MEN1 O00255 3/20 0.33
KMT2A Q03164 3/20 0.33
POLB P06746 2/20 0.33
CYP3A4 P08684 1/20 0.33
ALOX15 P16050 1/20 0.33
HSP90AA1 P07900 1/20 0.33
CDK5 Q00535 1/20 0.33
CDK5R1 Q15078 1/20 0.33
MCL1 Q07820 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
NQO2 P16083 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10470349 0.95 MAPT (0.40) MAPTCYP1A2CYP2C9CYP2C19ALDH1A1
SCHEMBL10471621 0.91 MAPT (0.38) MAPTCYP1A2CYP2C9CYP2C19ALDH1A1
SCHEMBL9832618 0.89 PGR (0.40) MAPTCYP1A2CYP2C9CYP2C19ALDH1A1
SCHEMBL10470963 0.86 MAPT (0.38) MAPTCYP1A2CYP2C9CYP2C19ALDH1A1
SCHEMBL9832370 0.84 PGR (0.40) MAPTCYP1A2CYP2C9CYP2C19ALDH1A1
SCHEMBL9832325 0.83 MAPT (0.39) MAPTCYP1A2CYP2C9CYP2C19ALDH1A1
SCHEMBL10470471 0.83 IDO1 (0.41) MAPTALDH1A1LMNAIDO1MEN1
SCHEMBL9833814 0.81 ALDH1A1 (0.39) MAPTCYP1A2CYP2C9CYP2C19ALDH1A1
SCHEMBL9833104 0.79 PGR (0.48) MAPTCYP1A2CYP2C9CYP2C19ALDH1A1
SCHEMBL9831495 0.78 CYP1A2 (0.37) MAPTCYP1A2CYP2C9CYP2C19ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4963686-A INTERMEDIATES FOR INOTROPIC AGENTS BOEHRINGER MANNHEIM GMBH (DE) 1990-10-16 US disclosed