SCHEMBL10471102

SCHEMBL10471102

Cc1c(C(=O)O)ccc2cc(-c3ccc4c(c3)C(C)(C)CCC4(C)C)oc12

nearest known ligand 0.52

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
RARA P10276 14/20 0.52
RARB P10826 14/20 0.52
RARG P13631 14/20 0.52
RXRA P19793 5/20 0.52
ABCB1 P08183 1/20 0.48
ABCC1 P33527 1/20 0.48
CYP26A1 O43174 1/20 0.43
CYP26B1 Q9NR63 1/20 0.43
RXRB P28702 1/20 0.40
RXRG P48443 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9856398 0.78 RARB (0.62) RARARARBRARGRXRAABCB1
SCHEMBL8461971 0.76 RARB (0.67) RARARARBRARGRXRAABCB1
SCHEMBL9359800 0.73 RARB (0.52) RARARARBRARGRXRAABCB1
SCHEMBL7647113 0.71 ABCB1 (0.69) RARARARBRARGRXRAABCB1
SCHEMBL9856250 0.70 RARB (0.53) RARARARBRARGRXRAABCB1
SCHEMBL9857155 0.70 RARB (0.54) RARARARBRARGRXRAABCB1
SCHEMBL9856299 0.69 RARB (0.56) RARARARBRARGRXRACYP26A1
SCHEMBL9281896 0.69 RARA (0.50) RARARARBRARGRXRAABCB1
SCHEMBL9551739 0.69 RARB (0.69) RARARARBRARGRXRAABCB1
SCHEMBL10356134 0.69 RARG (0.64) RARARARBRARGRXRARXRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4920140-A Skin disorders CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. (FR) 1990-04-24 US disclosed