Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.41 |
| ▸ | BCHE | P06276 | 3/20 | 0.41 |
| ▸ | MAOB | P27338 | 4/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | XIAP | P98170 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10473371 | 0.86 | ACHE (0.43) | ACHEBCHEMAOBMAOAFFAR1 | |
| SCHEMBL10473557 | 0.85 | ACHE (0.42) | ACHEBCHEMAOBMAOA | |
| SCHEMBL10473638 | 0.84 | ACHE (0.43) | ACHEBCHEMAOBMAOAFFAR1 | |
| SCHEMBL10472684 | 0.84 | PDE4A (0.34) | XIAP | |
| SCHEMBL10473364 | 0.82 | NOTUM (0.43) | IGF1R | |
| SCHEMBL10471821 | 0.82 | GPR84 (0.35) | ACHEBCHEMAOBMAOAEGFR | |
| SCHEMBL11157519 | 0.79 | KDM4E (0.37) | MAOBMAOAXIAPFFAR1 | |
| SCHEMBL10654980 | 0.78 | NOTUM (0.36) | XIAP | |
| SCHEMBL10474094 | 0.76 | ACHE (0.41) | ACHEBCHEMAOBMAOAFFAR1 | |
| SCHEMBL10472659 | 0.75 | ACHE (0.41) | ACHEBCHEMAOBMAOAFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4920221-A | CENTRAL NERVOUS SYSTEM ACTIVE AGENTS | PFIZER INC. (US) | 1990-04-24 | — | — | US | disclosed |
| EP-0090526-B1 | SUBSTITUTED DODECAHYDROTRIPHENYLENES, DECAHYDRO-1H-CYCLOPENTA(1)PHENANTHRENES, DECAHYDRO-1H-PYRIDO(1,2-F)PHENANTHRIDINES AND DECAHYDROPYRROLO(1,2-F)PHENANTHRIDINES AS CNS AGENTS | PFIZER INC. (US) | 1986-11-26 | — | — | EP | disclosed |