Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL102461 | 0.82 | POLB (0.51) | MEN1KMT2ALMNAMAPTPOLB | |
| SCHEMBL105355 | 0.77 | LMNA (0.65) | MEN1KMT2ALMNAMAPTRECQL | |
| SCHEMBL102269 | 0.77 | MEN1 (0.58) | MEN1KMT2ALMNAMAPTPKM | |
| SCHEMBL102133 | 0.75 | MAPT (0.54) | LMNAMAPTRECQLPKMPOLB | |
| SCHEMBL103022 | 0.65 | POLB (0.49) | MEN1KMT2ALMNAPOLBL3MBTL1 | |
| SCHEMBL4203901 | 0.65 | MEN1 (0.51) | MEN1KMT2ALMNAMAPTRECQL | |
| SCHEMBL102294 | 0.65 | POLB (0.55) | MEN1KMT2ALMNAMAPTPOLB | |
| SCHEMBL9570011 | 0.62 | POLB (0.58) | MEN1KMT2ALMNAPOLBL3MBTL1 | |
| SCHEMBL3678249 | 0.62 | GRM5 (0.55) | MEN1KMT2AL3MBTL1 | |
| SCHEMBL103864 | 0.61 | PSMB8 (0.48) | MAPTHDAC6TP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426115-A2 | Alkynyl derivatives as modulators of metabotropic glutamate receptors | Addex Pharma SA (CH) | 2012-03-07 | — | — | EP | disclosed |