Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | NPY1R | P25929 | 1/20 | 0.62 |
| ▸ | NPY2R | P49146 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | PDE3B | Q13370 | 10/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PDE2A | O00408 | 1/20 | 0.46 |
| ▸ | PDE1A | P54750 | 1/20 | 0.46 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.46 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 4/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10463523 | 0.86 | KCNH2 (0.53) | LMNANPY1RNPY2RMAPTKCNH2 | |
| SCHEMBL10465918 | 0.85 | KCNH2 (0.56) | LMNANPY1RNPY2RMAPTKCNH2 | |
| SCHEMBL21970671 | 0.85 | KCNH2 (0.61) | LMNANPY1RNPY2RMAPTKCNH2 | |
| SCHEMBL10464834 | 0.79 | LMNA (0.50) | LMNANPY1RNPY2RMAPTKCNH2 | |
| SCHEMBL9815919 | 0.78 | LMNA (0.65) | LMNANPY1RNPY2RMAPTKCNH2 | |
| SCHEMBL10464942 | 0.78 | LMNA (0.52) | LMNANPY1RNPY2RMAPTKCNH2 | |
| SCHEMBL22910067 | 0.77 | KCNH2 (0.66) | LMNANPY1RNPY2RMAPTKCNH2 | |
| SCHEMBL10619654 | 0.77 | LMNA (0.47) | LMNANPY1RNPY2RMAPTSMN1; SMN2 | |
| SCHEMBL10967326 | 0.77 | LMNA (1.00) | LMNANPY1RNPY2RMAPTKCNH2 | |
| SCHEMBL10464826 | 0.77 | LMNA (0.45) | LMNANPY1RNPY2RMAPTKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0042107-B1 | DIHYDROPYRIDAZINONES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS | BASF Aktiengesellschaft (DE) | 1985-04-03 | — | — | EP | claimed |
| US-4410529-A | HYPOTENSIVE AGNENTS, ANTICOAGULANTS | BASF AKTIENGESELLSCHAFT (DE) | 1983-10-18 | — | — | US | claimed |
| EP-0042107-A1 | Dihydropyridazinones, processes for their preparation and pharmaceutical compositions containing these compounds | BASF Aktiengesellschaft (DE) | 1981-12-23 | — | — | EP | claimed |
| EP-0012338-A1 | Dihydropyridazinones, process for their preparation and therapeutical agents containing them | BASF Aktiengesellschaft (DE) | 1980-06-25 | — | — | EP | claimed |
| US-4965263-A | HYPOTENSIVE AGENTS | MITSUI TOATSU KAGAKU KABUSHIKI KAISHA (JP) | 1990-10-23 | — | — | US | disclosed |
| EP-0090978-B1 | IMIDAZOLYLPHENYL-TETRAHYDROPYRIDAZINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | A. Nattermann & Cie. GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |
| EP-0107735-B1 | NOVEL PYRIDAZINONE DERIVATIVES | MITSUI TOATSU KAGAKU KABUSHIKI KAISHA (JP) | 1988-10-19 | — | — | EP | disclosed |
| US-4639451-A | HYPOTENSIVE AGENTS, ANTICOAGULANTS | MITSUI TOATSU KAGAKU-KABUSHIKI KAISHA (JP) | 1987-01-27 | — | — | US | disclosed |
| EP-0042107-B1 | DIHYDROPYRIDAZINONES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS | BASF Aktiengesellschaft (DE) | 1985-04-03 | — | — | EP | disclosed |
| EP-0107735-A1 | NOVEL PYRIDAZINONE DERIVATIVES | MITSUI TOATSU KAGAKU KABUSHIKI KAISHA (JP) | 1984-05-09 | — | — | EP | disclosed |
| US-4410529-A | HYPOTENSIVE AGNENTS, ANTICOAGULANTS | BASF AKTIENGESELLSCHAFT (DE) | 1983-10-18 | — | — | US | disclosed |
| US-4410529-A | HYPOTENSIVE AGNENTS, ANTICOAGULANTS | BASF AKTIENGESELLSCHAFT (DE) | 1983-10-18 | — | — | US | disclosed |
| EP-0090978-A2 | Imidazolylphenyl-tetrahydropyridazines, process for their preparation and pharmaceutical compositions containing them | A. Nattermann & Cie. GmbH (DE) | 1983-10-12 | — | — | EP | disclosed |
| EP-0042107-A1 | Dihydropyridazinones, processes for their preparation and pharmaceutical compositions containing these compounds | BASF Aktiengesellschaft (DE) | 1981-12-23 | — | — | EP | disclosed |
| EP-0042107-A1 | Dihydropyridazinones, processes for their preparation and pharmaceutical compositions containing these compounds | BASF Aktiengesellschaft (DE) | 1981-12-23 | — | — | EP | disclosed |
| EP-0012338-A1 | Dihydropyridazinones, process for their preparation and therapeutical agents containing them | BASF Aktiengesellschaft (DE) | 1980-06-25 | — | — | EP | disclosed |
| EP-0012338-A1 | Dihydropyridazinones, process for their preparation and therapeutical agents containing them | BASF Aktiengesellschaft (DE) | 1980-06-25 | — | — | EP | disclosed |