Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 8/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.47 |
| ▸ | PDE4A | P27815 | 3/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10474304 | 0.83 | PDE3B (0.50) | KMT2APDE3BPDE3APDE4BPDE4A | |
| SCHEMBL9657441 | 0.82 | PDE3B (0.47) | KMT2APDE3BPDE3APDE4BPDE4A | |
| SCHEMBL10867608 | 0.81 | PDE4B (0.48) | KMT2APDE3BPDE3APDE4BPDE4A | |
| SCHEMBL4573757 | 0.81 | PDE3B (0.54) | KMT2APDE3BPDE3APDE4BPDE4A | |
| SCHEMBL4573518 | 0.81 | PDE3B (0.52) | KMT2AMEN1PDE3BPDE3APDE4B | |
| SCHEMBL9526509 | 0.80 | LMNA (0.51) | KMT2APDE3BPDE3APDE4BPDE4A | |
| SCHEMBL9657454 | 0.80 | PDE3B (0.45) | KMT2APDE3BPDE3APDE4BPDE4A | |
| SCHEMBL7337123 | 0.80 | PDE3B (0.46) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL10475455 | 0.80 | HPGD (0.49) | KMT2APDE3BPDE3APDE4BPDE4A | |
| SCHEMBL7326426 | 0.80 | PDE3B (0.47) | KMT2APDE3BPDE3APDE4BPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4914093-A | CARDIOVASCULAR DISORDERS | SANKYO COMPANY LIMITED (JP) | 1990-04-03 | — | — | US | disclosed |
| EP-0330242-A1 | Pyridazinone derivatives, their preparation and use | Sankyo Company Limited (JP) | 1989-08-30 | — | — | EP | disclosed |
| EP-0178189-A2 | Pyridazinone derivatives, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1986-04-16 | — | — | EP | disclosed |