Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.63 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.46 |
| ▸ | FUT7 | Q11130 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 9/20 | 0.45 |
| ▸ | CNR2 | P34972 | 9/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31185907 | 0.87 | PTGS2 (0.73) | PTGS2GPR84FUT7CNR1CNR2 | |
| SCHEMBL31185803 | 0.87 | PTGS2 (0.73) | PTGS2GPR84FUT7CNR1CNR2 | |
| SCHEMBL31185832 | 0.87 | PTGS2 (0.73) | PTGS2GPR84FUT7CNR1CNR2 | |
| SCHEMBL18586439 | 0.87 | PTGS2 (0.73) | PTGS2GPR84FUT7CNR1CNR2 | |
| SCHEMBL28158495 | 0.87 | PTGS2 (0.57) | PTGS2GPR84FUT7CYP3A4 | |
| SCHEMBL31628722 | 0.87 | PTGS2 (0.57) | PTGS2GPR84FUT7CYP3A4 | |
| SCHEMBL19900643 | 0.87 | PTGS2 (0.57) | PTGS2GPR84FUT7CYP3A4 | |
| SCHEMBL16835705 | 0.87 | PTGS2 (0.57) | PTGS2GPR84FUT7CYP3A4 | |
| SCHEMBL1171756 | 0.85 | PTGS2 (0.76) | PTGS2GPR84FUT7CNR1CNR2 | |
| SCHEMBL22001025 | 0.84 | PTGS2 (0.69) | PTGS2GPR84FUT7CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4920221-A | CENTRAL NERVOUS SYSTEM ACTIVE AGENTS | PFIZER INC. (US) | 1990-04-24 | — | — | US | disclosed |
| US-4642373-A | Substituted dodecahydrotripheylenes, and decahydropyrrolo[1,2-f]phenanthridines as CNS agents | PFIZER INC. (US) | 1987-02-10 | — | — | US | disclosed |
| US-4576964-A | ANALGESICS, ANTIEMETICS | PFIZER INC. (US) | 1986-03-18 | — | — | US | disclosed |
| US-4476131-A | ANTIEMETICS, ANALGESICS | PFIZER INC. (US) | 1984-10-09 | — | — | US | disclosed |
| US-4473704-A | ANALGESICS, ANTIEMETICS | PFIZER INC. (US) | 1984-09-25 | — | — | US | disclosed |