Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.52 |
| ▸ | ESR1 | P03372 | 2/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.47 |
| ▸ | TACR2 | P21452 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SHBG | P04278 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28158495 | 1.00 | PTGS2 (0.57) | PTGS2CYP3A4GPR84ESR1ADRA2A | |
| SCHEMBL31628722 | 1.00 | PTGS2 (0.57) | PTGS2CYP3A4GPR84ESR1ADRA2A | |
| SCHEMBL19900643 | 1.00 | PTGS2 (0.57) | PTGS2CYP3A4GPR84ESR1ADRA2A | |
| SCHEMBL28295239 | 0.92 | KCNH2 (0.50) | PTGS2CYP3A4GPR84ESR1ADRA2A | |
| SCHEMBL9122379 | 0.88 | PTGS2 (0.70) | PTGS2CYP3A4GPR84ESR1ADRA2A | |
| SCHEMBL8560359 | 0.88 | PTGS2 (0.70) | PTGS2CYP3A4GPR84ESR1ADRA2A | |
| SCHEMBL7628223 | 0.88 | PTGS2 (0.70) | PTGS2CYP3A4GPR84ESR1ADRA2A | |
| SCHEMBL10474252 | 0.87 | PTGS2 (0.63) | PTGS2CYP3A4GPR84FUT7 | |
| SCHEMBL9420945 | 0.85 | PTGS2 (0.67) | PTGS2CYP3A4GPR84ESR1ADRA2A | |
| SCHEMBL2871788 | 0.85 | PTGS2 (0.68) | PTGS2CYP3A4GPR84ESR1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10155798-B2 | Anti-obesity compounds derived from neuromedin U | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-12-18 | — | — | US | disclosed |
| WO-2017044592-A1 | CONJUGATED ANTICANCER SMAC ANALOGS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-03-16 | — | — | WO | disclosed |
| US-20170037103-A1 | Anti-Obesity Compounds Derived from Neuromedin U | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-02-09 | — | — | US | disclosed |
| WO-2015095719-A1 | ANTI-OBESITY COMPOUNDS DERIVED FROM NEUROMEDIN U | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170037103-A1 | Anti-Obesity Compounds Derived from Neuromedin U | NMUR1, NMUR2, NMBR | PTGS2 4438/4885CYP3A4 4852/4885GPR84 399/4885 |
| US-10155798-B2 | Anti-obesity compounds derived from neuromedin U | NMUR1, NMUR2, NMBR | PTGS2 4438/4885CYP3A4 4852/4885GPR84 399/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.