Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | NPY1R | P25929 | 1/20 | 0.65 |
| ▸ | NPY2R | P49146 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7326890 | 0.89 | MAPT (0.55) | MAPTLMNANPY1RNPY2RKMT2A | |
| SCHEMBL7362081 | 0.84 | MAPT (0.51) | MAPTLMNANPY1RNPY2RKMT2A | |
| SCHEMBL8265386 | 0.84 | MAPT (0.50) | MAPTLMNANPY1RNPY2RKMT2A | |
| SCHEMBL7329667 | 0.84 | MAPT (0.55) | MAPTLMNANPY1RNPY2RKMT2A | |
| SCHEMBL9630235 | 0.82 | MAPT (0.67) | MAPTLMNANPY1RNPY2RKMT2A | |
| SCHEMBL7330323 | 0.80 | MAPT (0.65) | MAPTLMNANPY1RNPY2RKMT2A | |
| SCHEMBL7327646 | 0.80 | MAPT (0.65) | MAPTLMNANPY1RNPY2RKMT2A | |
| SCHEMBL5912716 | 0.79 | MAPT (0.64) | MAPTLMNANPY1RNPY2RKMT2A | |
| SCHEMBL8265597 | 0.79 | MAPT (0.45) | MAPTLMNANPY1RNPY2RKMT2A | |
| SCHEMBL14198714 | 0.79 | MAPT (0.45) | MAPTLMNANPY1RNPY2RKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4914093-A | CARDIOVASCULAR DISORDERS | SANKYO COMPANY LIMITED (JP) | 1990-04-03 | — | — | US | disclosed |
| EP-0330242-A1 | Pyridazinone derivatives, their preparation and use | Sankyo Company Limited (JP) | 1989-08-30 | — | — | EP | disclosed |
| EP-0178189-A2 | Pyridazinone derivatives, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1986-04-16 | — | — | EP | disclosed |