Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | NPY1R | P25929 | 1/20 | 0.55 |
| ▸ | NPY2R | P49146 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10474306 | 0.89 | MAPT (0.65) | MAPTLMNANPY1RNPY2RKMT2A | |
| SCHEMBL7338149 | 0.88 | LMNA (0.61) | MAPTLMNANPY1RNPY2RKMT2A | |
| SCHEMBL7362081 | 0.84 | MAPT (0.51) | MAPTLMNANPY1RNPY2RKMT2A | |
| SCHEMBL7337123 | 0.84 | PDE3B (0.46) | MAPTLMNANPY1RNPY2RPDE3B | |
| SCHEMBL8265386 | 0.84 | MAPT (0.50) | MAPTLMNANPY1RNPY2RKMT2A | |
| SCHEMBL7329667 | 0.84 | MAPT (0.55) | MAPTLMNANPY1RNPY2RKMT2A | |
| SCHEMBL7297671 | 0.82 | PDE3B (0.53) | MAPTLMNANPY1RNPY2RKMT2A | |
| SCHEMBL7329341 | 0.82 | FAAH (0.41) | MAPTADORA2BADORA2ASMN1; SMN2CYP3A4 | |
| SCHEMBL5912716 | 0.82 | MAPT (0.64) | MAPTLMNANPY1RNPY2RKMT2A | |
| SCHEMBL7330323 | 0.80 | MAPT (0.65) | MAPTLMNANPY1RNPY2RKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5204463-A | Substituted methoxyphenyl-4,5 dihydro-3(2H)-pridazinones having cardiotonic and beta blocking activities | GLAXO INC. (US) | 1993-04-20 | — | — | US | disclosed |
| US-5096904-A | Congestive heart failure | GLAXO INC. (US) | 1992-03-17 | — | — | US | disclosed |
| US-5053338-A | Hydrolysis of ester to obtain an optically enriched mixture of a phenol enantiomer | GLAXO INC. (US) | 1991-10-01 | — | — | US | disclosed |
| EP-0412814-A2 | Pyridazinones having cardiotonic and beta blocking activity | GLAXO WELLCOME INC. (US) | 1991-02-13 | — | — | EP | disclosed |