Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | NPY1R | P25929 | 1/20 | 0.65 |
| ▸ | NPY2R | P49146 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7336619 | 0.87 | LMNA (0.72) | MAPTLMNANPY1RNPY2RKMT2A | |
| SCHEMBL4892521 | 0.85 | MAPT (0.49) | MAPTLMNANPY1RNPY2RKMT2A | |
| SCHEMBL9630235 | 0.85 | MAPT (0.67) | MAPTLMNANPY1RNPY2RKMT2A | |
| SCHEMBL10968693 | 0.84 | MAPT (0.79) | MAPTLMNANPY1RNPY2RKMT2A | |
| SCHEMBL7330323 | 0.83 | MAPT (0.65) | MAPTLMNANPY1RNPY2RKMT2A | |
| SCHEMBL4573518 | 0.83 | PDE3B (0.52) | MAPTLMNANPY1RNPY2RKMT2A | |
| SCHEMBL5912716 | 0.82 | MAPT (0.64) | MAPTLMNANPY1RNPY2RKMT2A | |
| SCHEMBL9834011 | 0.82 | KDM4E (0.48) | MAPTLMNANPY1RNPY2RKDM4E | |
| SCHEMBL9461663 | 0.81 | GAA (0.46) | MAPTLMNANPY1RNPY2RKDM4E | |
| SCHEMBL10474306 | 0.80 | MAPT (0.65) | MAPTLMNANPY1RNPY2RKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-63141970-A | — | — | None | — | — | JP | disclosed |
| US-5204463-A | Substituted methoxyphenyl-4,5 dihydro-3(2H)-pridazinones having cardiotonic and beta blocking activities | GLAXO INC. (US) | 1993-04-20 | — | — | US | disclosed |
| US-5096904-A | Congestive heart failure | GLAXO INC. (US) | 1992-03-17 | — | — | US | disclosed |
| US-5053338-A | Hydrolysis of ester to obtain an optically enriched mixture of a phenol enantiomer | GLAXO INC. (US) | 1991-10-01 | — | — | US | disclosed |
| EP-0412814-A2 | Pyridazinones having cardiotonic and beta blocking activity | GLAXO WELLCOME INC. (US) | 1991-02-13 | — | — | EP | disclosed |
| JP-S63141970-A | 4,5-DIHYDRO-6-(4-SUBSTITUTED PHENYL)-3(2H)-PYRIDAZINONE DERIVATIVE | MORISHITA SEIYAKU KK | 1988-06-14 | — | — | JP | disclosed |