SCHEMBL1047599

SCHEMBL1047599

Cc1cc(C(F)(F)F)nn1CC(=O)N1CCC(c2nc(C[S+]([O-])c3ccc4ncccc4c3)cs2)CC1

nearest known ligand 0.43

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.38
CCR1 P32246 1/20 0.37
KDM4E B2RXH2 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
ORAI1 Q96D31 1/20 0.34
SPR P35270 1/20 0.33
IRAK4 Q9NWZ3 4/20 0.33
POLB P06746 2/20 0.33
TSHR P16473 1/20 0.33
CXCR3 P49682 1/20 0.31
TRPV1 Q8NER1 1/20 0.31
LMNA P02545 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1047598 0.87 GAA (0.39) GAACCR1KDM4ECYP1A2CYP3A4
SCHEMBL1046923 0.87 GAA (0.40) GAACCR1KDM4ECYP1A2CYP3A4
SCHEMBL1046910 0.86 GAA (0.40) GAACCR1KDM4ECYP1A2CYP3A4
SCHEMBL1044102 0.83 GAA (0.40) GAACCR1KDM4ECYP1A2CYP3A4
SCHEMBL1046643 0.80 GAA (0.47) GAACCR1KDM4ESPRPOLB
SCHEMBL1047445 0.79 GAA (0.39) GAACCR1KDM4ESPRPOLB
SCHEMBL1046909 0.79 KDM4E (0.41) GAACCR1KDM4ECYP1A2CYP3A4
SCHEMBL13523714 0.79 GAA (0.50) GAACCR1KDM4ECYP1A2CYP3A4
SCHEMBL1046922 0.78 GAA (0.40) GAACCR1CYP1A2CYP3A4CYP2D6
SCHEMBL1775261 0.77 POLB (0.46) GAACCR1KDM4ECYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2272846-A1 Thiazolylpiperidine derivatives as fungicide Bayer CropScience AG (DE) 2011-01-12 EP disclosed