Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 11/20 | 0.70 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.52 |
| ▸ | MMP3 | P08254 | 1/20 | 0.52 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1504806 | 0.84 | ADAM17 (0.80) | ADAM17ADAM10MMP3ADAM9ALDH1A1 | |
| SCHEMBL15327563 | 0.83 | ADAM17 (1.00) | ADAM17ADAM10MMP3ADAM9 | |
| SCHEMBL1504458 | 0.83 | ADAM17 (1.00) | ADAM17ADAM10MMP3ADAM9 | |
| SCHEMBL1504853 | 0.79 | ADAM17 (0.58) | ADAM17ADAM10MMP3ADAM9ALDH1A1 | |
| SCHEMBL1504937 | 0.78 | ADAM17 (0.83) | ADAM17ADAM10MMP3ADAM9ALDH1A1 | |
| SCHEMBL1504741 | 0.78 | ADAM17 (0.83) | ADAM17ADAM10MMP3ADAM9ALDH1A1 | |
| SCHEMBL1504644 | 0.76 | ADAM17 (1.00) | ADAM17ADAM10MMP3ADAM9 | |
| SCHEMBL1504679 | 0.74 | ADAM17 (0.66) | ADAM17ADAM10MMP3ADAM9KMT2A | |
| SCHEMBL1504948 | 0.74 | ADAM17 (0.66) | ADAM17ADAM10MMP3ADAM9KMT2A | |
| SCHEMBL10276524 | 0.72 | ADAM17 (0.55) | ADAM17ALDH1A1POLBTP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2477968-A1 | N- [2-HYDROXYCARBAMOYL-2- (PIPERAZINYL) ETHYL]BENZAMIDE COMPOUNDS, THEIR PREPARATION AND THEIR USE AS TACE INHIBITORS | Galderma Research & Development (FR) | 2012-07-25 | — | — | EP | disclosed |