Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 10/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10476143 | 0.79 | ADAM17 (0.70) | ADAM17KMT2APOLBTP53ADAM10 | |
| SCHEMBL1504806 | 0.77 | ADAM17 (0.80) | ADAM17KMT2APOLBTP53ADAM10 | |
| SCHEMBL15327563 | 0.73 | ADAM17 (1.00) | ADAM17ADAM10MMP3ADAM9 | |
| SCHEMBL1504458 | 0.73 | ADAM17 (1.00) | ADAM17ADAM10MMP3ADAM9 | |
| SCHEMBL1504776 | 0.72 | ADAM17 (0.63) | ADAM17KMT2AADAM10MMP3 | |
| SCHEMBL1504674 | 0.72 | ADAM17 (0.61) | ADAM17ADAM10MMP3ADAM9ALDH1A1 | |
| SCHEMBL1504528 | 0.71 | ADAM17 (0.62) | ADAM17ADAM10MMP3ADAM9ALDH1A1 | |
| SCHEMBL1504741 | 0.71 | ADAM17 (0.83) | ADAM17ADAM10MMP3ADAM9ALDH1A1 | |
| SCHEMBL10724027 | 0.71 | TAS1R3 (0.58) | ADAM17KMT2APOLBTP53ALDH1A1 | |
| SCHEMBL1504682 | 0.70 | ADAM17 (0.41) | ADAM17KMT2APOLBADAM10MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011033009-A1 | N- [2-HYDROXYCARBAMOYL-2- (PIPERAZINYL) ETHYL] BENZAMIDE COMPOUNDS, THEIR PREPARATION AND THEIR USE AS TACE INHIBITORS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-03-24 | — | — | WO | disclosed |