Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.38 |
| ▸ | STAMBP | O95630 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL507842 | 0.99 | LSS (0.43) | LSSMAPK14CHRM3NAMPTEPHX2 | |
| SCHEMBL10476134 | 0.94 | MLYCD (0.47) | LSSMAPK14CHRM3NAMPTEPHX2 | |
| SCHEMBL508437 | 0.91 | LMNA (0.49) | PPARGPOLBSMN1; SMN2HDAC1HDAC4 | |
| SCHEMBL10476163 | 0.89 | EPHX2 (0.40) | CHRM3EPHX2PPARGPPARAKMT2A | |
| SCHEMBL10476267 | 0.86 | PPARG (0.45) | CHRM3EPHX2PPARGHDAC1HDAC4 | |
| Hydrochloric Acid SCHEMBL507616 | 0.85 | PPARG (0.44) | CHRM3EPHX2PPARGHDAC1HDAC4 | |
| Succinic Acid SCHEMBL507971 | 0.85 | PPARD (0.38) | CHRM3EPHX2PPARGPPARAKMT2A | |
| SCHEMBL10476291 | 0.85 | EPHX2 (0.47) | EPHX2PPARGPPARA | |
| SCHEMBL10476165 | 0.84 | HTR2C (0.37) | LSSMEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL10278060 | 0.84 | MEN1 (0.39) | NAMPTMEN1CYP1A2CYP2C19KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8580780-B2 | 6 substituted 2, 3,4,5 tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonist | ELI LILLY AND COMPANY (US) | 2013-11-12 | — | — | US | claimed |
| EP-2479168-A1 | 6-Substituted 2,3,4,5-Tetrahydro-1H-Benzo [d]Azepines as 5-HT2C Receptor Agonists | ELI LILLY AND COMPANY (US) | 2012-07-25 | — | — | EP | claimed |