SCHEMBL10477667

SCHEMBL10477667

O=[C][C@H](Cc1cccc2ccccc12)NC(=O)OCc1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CASP1 P29466 6/20 0.54
ALDH1A1 P00352 1/20 0.48
CYP1A2 P05177 1/20 0.48
CYP3A4 P08684 1/20 0.48
CYP2C9 P11712 1/20 0.48
HPGD P15428 1/20 0.48
CYP2C19 P33261 1/20 0.48
HSD17B10 Q99714 1/20 0.48
CTSB P07858 3/20 0.48
CTSS P25774 3/20 0.48
CTSL P07711 2/20 0.48
HRH4 Q9H3N8 1/20 0.48
TACR1 P25103 3/20 0.48
HDAC3 O15379 1/20 0.48
HDAC4 P56524 1/20 0.48
HDAC1 Q13547 1/20 0.48
HDAC7 Q8WUI4 1/20 0.48
HDAC2 Q92769 1/20 0.48
HDAC10 Q969S8 1/20 0.48
HDAC11 Q96DB2 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10722104 1.00 CASP1 (0.54) CASP1ALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL10720594 0.92 CASP1 (0.55) CASP1CTSBCTSSCTSLHRH4
SCHEMBL10720588 0.92 CASP1 (0.55) CASP1CTSBCTSSCTSLHRH4
SCHEMBL10722820 0.85 CTSL (0.49) ALDH1A1CTSBCTSSCTSLTACR1
SCHEMBL10722813 0.85 CTSL (0.49) ALDH1A1CTSBCTSSCTSLTACR1
SCHEMBL7444765 0.84 CASP1 (0.63) CASP1HRH4TACR1HDAC1HDAC2
SCHEMBL29523231 0.84 CASP1 (0.63) CASP1HRH4TACR1HDAC1HDAC2
SCHEMBL10976664 0.84 CASP1 (0.63) CASP1HRH4TACR1HDAC1HDAC2
SCHEMBL29523440 0.84 CASP1 (0.63) CASP1HRH4TACR1HDAC1HDAC2
SCHEMBL7277023 0.84 CASP1 (0.63) CASP1HRH4TACR1HDAC1HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4857650-A Novel renin inhibitory amino acid derivatives KISSEI PHARMACEUTICAL CO., LTD. (JP) 1989-08-15 US disclosed
US-4853463-A Amino acid derivatives KISSEI PHARMACEUTICAL CO., LTD. (JP) 1989-08-01 US disclosed
US-4841067-A RENIN INHIBITORS KISSEI PHARMACEUTICAL CO., LTD. (JP) 1989-06-20 US disclosed
US-4698329-A HYPOTENSIVE AGENTS SANKYO COMPANY, LIMITED (JP) 1987-10-06 US disclosed
US-4656269-A RENIN INHIBITORY EFFECT WHEN ADMINISTERING ORALLY; HYPOTENSIVE AGENTS KISSEI PHARMACEUTICAL CO., LTD. (JP) 1987-04-07 US disclosed
EP-0206807-A2 Novel amino acid derivatives Kissei Pharmaceutical Co. Ltd. (JP) 1986-12-30 EP disclosed
EP-0200406-A2 Novel amino acid derivatives Kissei Pharmaceutical Co. Ltd. (JP) 1986-11-05 EP disclosed
EP-0190891-A2 Novel amino acid derivatives Kissei Pharmaceutical Co. Ltd. (JP) 1986-08-13 EP disclosed
EP-0152255-A2 New renin-inhibitory peptides and their use SANKYO COMPANY LIMITED (JP) 1985-08-21 EP disclosed