SCHEMBL10478232

SCHEMBL10478232

Cc1c(C)c(C)c2c(c1C)-c1ccccc1-2

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.39
ACHE P22303 2/20 0.39
MEN1 O00255 5/20 0.37
KMT2A Q03164 5/20 0.37
ALDH1A1 P00352 5/20 0.37
KDM4E B2RXH2 3/20 0.37
MAPT P10636 3/20 0.37
TDP1 Q9NUW8 2/20 0.37
USP2 O75604 2/20 0.37
DUSP3 P51452 1/20 0.37
LMNA P02545 3/20 0.37
ALOX12 P18054 1/20 0.37
HSD11B1 P28845 1/20 0.36
CDC25B P30305 3/20 0.35
CYP3A4 P08684 2/20 0.34
PDCD1 Q15116 1/20 0.34
CD274 Q9NZQ7 1/20 0.34
HSD17B10 Q99714 1/20 0.34
SMN1; SMN2 Q16637 3/20 0.33
CDC25A P30304 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4791822 0.97 MEN1 (0.38) TSHRACHEMEN1KMT2AALDH1A1
SCHEMBL9803179 0.84 MAPT (0.54) TSHRMEN1KMT2AALDH1A1KDM4E
SCHEMBL2522961 0.84 CDC25B (0.35) TSHRMEN1KMT2AALDH1A1KDM4E
SCHEMBL18668605 0.81 TSHR (0.43) TSHRACHEMEN1KMT2AALDH1A1
SCHEMBL28844141 0.79 TSHR (0.47) TSHRACHEALDH1A1CYP3A4SMN1; SMN2
SCHEMBL25316689 0.79 ALDH1A1 (0.38) TSHRMEN1KMT2AALDH1A1KDM4E
SCHEMBL31603849 0.79 ALDH1A1 (0.38) TSHRMEN1KMT2AALDH1A1KDM4E
SCHEMBL9510889 0.77 MEN1 (0.55) TSHRMEN1KMT2AALDH1A1KDM4E
SCHEMBL5027074 0.76 LMNA (0.47) TSHRACHEMEN1KMT2AALDH1A1
SCHEMBL1598488 0.75 HPGD (0.48) TSHRMEN1KMT2AALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104254555-A Epoxy resin composition, resin sheet, cured product and phenoxy resin NIPPON STEEL & SUMIKIN CHEM CO 2014-12-31 CN claimed
CN-104254555-A Epoxy resin composition, resin sheet, cured product and phenoxy resin NIPPON STEEL & SUMIKIN CHEM CO 2014-12-31 CN disclosed
CN-101622310-B Polylactic acid composition TEIJIN LTD 2012-11-14 CN disclosed
CN-101622310-A Polylactic acid composition TEIJIN LTD 2010-01-06 CN disclosed
CN-1219820-C Acrylic rubber composition and vulcanizate ZEON CORP (JP) 2005-09-21 CN disclosed
CN-1505659-A Acrylic rubber composition and vulcanized rubber �ձ�������ʽ���� 2004-06-16 CN disclosed
US-4871816-A Triblock polyarylene polyether with polysiloxane segment and impact-improved blends thereof THE B.F. GOODRICH COMPANY (US) 1989-10-03 US disclosed