Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.32 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.32 |
| ▸ | ITGAV | P06756 | 1/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.32 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.32 |
| ▸ | ITGAL | P20701 | 1/20 | 0.32 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.31 |
| ▸ | CAD | P27708 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dihydroorotate SCHEMBL29901858 | 0.81 | CAD (0.43) | CRBNITGB3ITGB2ITGB1ITGAV | |
| Dihydroorotate SCHEMBL417324 | 0.81 | CAD (0.43) | CRBNITGB3ITGB2ITGB1ITGAV | |
| Dihydroorotate SCHEMBL121953 | 0.81 | CAD (0.43) | CRBNITGB3ITGB2ITGB1ITGAV | |
| Dihydroorotate SCHEMBL758070 | 0.81 | CAD (0.43) | CRBNITGB3ITGB2ITGB1ITGAV | |
| SCHEMBL8195841 | 0.79 | CRBN (0.33) | CRBNITGB3ITGB2ITGB1ITGAV | |
| SCHEMBL23182639 | 0.75 | CRBN (0.38) | CRBNITGB3ITGB2ITGB1ITGAV | |
| SCHEMBL14528005 | 0.75 | CRBN (0.38) | CRBNITGB3ITGB2ITGB1ITGAV | |
| SCHEMBL6652022 | 0.75 | MEN1 (0.38) | CRBNITGB3ITGB2ITGB1ITGAV | |
| SCHEMBL13219138 | 0.75 | CRBN (0.38) | CRBNITGB3ITGB2ITGB1ITGAV | |
| Dihydroorotate SCHEMBL27883318 | 0.73 | CRBN (0.32) | CRBNITGB3ITGB2ITGB1ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4873228-A | 2-oxo-4-carboxy-pyrimidines and their use as anti-malaria and anti-cancer agents | THE UNIVERSITY OF MELBOURNE (AU) | 1989-10-10 | — | — | US | disclosed |
| EP-0260057-A2 | 2-Oxo-4-carboxy-pyrimidines | THE UNIVERSITY OF MELBOURNE (AU) | 1988-03-16 | — | — | EP | disclosed |