Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 2/20 | 0.47 |
| ▸ | MC5R | P33032 | 2/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | MC3R | P41968 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA6 | P23280 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MPO | P05164 | 2/20 | 0.37 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24477135 | 0.84 | MC4R (0.55) | MC4RMC5RCHRM2MC3RCA12 | |
| SCHEMBL25377753 | 0.81 | LMNA (0.44) | CHRM2IDO1CA12CA9MEN1 | |
| SCHEMBL10480660 | 0.80 | TAAR1 (0.58) | MC4RMC5RCHRM2MC3RIDO1 | |
| SCHEMBL29604560 | 0.79 | TDP1 (0.55) | MC4RMC5RCHRM2MC3RCA12 | |
| SCHEMBL10483931 | 0.79 | NOS1 (0.51) | MC4RMC5RCHRM2MC3RMPO | |
| SCHEMBL10441286 | 0.78 | CHRM2 (0.39) | CHRM2IDO1MEN1KMT2AMPO | |
| SCHEMBL28300111 | 0.78 | GSR (0.50) | CHRM2IDO1MEN1KMT2AMPO | |
| SCHEMBL1568357 | 0.78 | CHRM2 (0.70) | MC4RMC5RCHRM2CA12MPO | |
| SCHEMBL16151783 | 0.75 | MC4R (0.58) | MC4RMC5RCHRM2MC3RCA12 | |
| SCHEMBL625735 | 0.74 | CHRM2 (0.48) | MC4RMC5RCHRM2MC3RIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0329900-A1 | Substituted 1-aralkyl imidazoline-2-thiols | SMITHKLINE BEECHAM CORPORATION (US) | 1989-08-30 | — | — | EP | claimed |
| US-4876266-A | DOPAMINE-B-HYDROXYLASE INHIBITORS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-10-24 | — | — | US | disclosed |
| EP-0329900-A1 | Substituted 1-aralkyl imidazoline-2-thiols | SMITHKLINE BEECHAM CORPORATION (US) | 1989-08-30 | — | — | EP | disclosed |
| WO-1989006126-A1 | 1-ARALKYL-2-MERCAPTOIMIDAZOLINES AS DOPAMINE-beta-HYDROXYLASE INHIBITORS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-07-13 | — | — | WO | disclosed |