Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 10/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.79 |
| ▸ | RAB9A | P51151 | 3/20 | 0.79 |
| ▸ | NPC1 | O15118 | 2/20 | 0.79 |
| ▸ | LMNA | P02545 | 2/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 1/20 | 0.73 |
| ▸ | HTT | P42858 | 1/20 | 0.73 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.73 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.65 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.60 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12090219 | 0.92 | NAMPT (0.84) | NAMPTMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL12090170 | 0.88 | NAMPT (0.81) | NAMPTMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL998206 | 0.88 | NAMPT (1.00) | NAMPTMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL7844235 | 0.86 | LMNA (0.78) | NAMPTMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL13483867 | 0.85 | LMNA (1.00) | NAMPTMEN1KMT2ARAB9ALMNA | |
| SCHEMBL12078582 | 0.85 | NAMPT (0.84) | NAMPTMEN1KMT2ATRPV1 | |
| SCHEMBL12078275 | 0.85 | NAMPT (1.00) | NAMPTMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL12335301 | 0.81 | KMT2A (0.87) | NAMPTMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL14324802 | 0.81 | KMT2A (0.87) | NAMPTMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL12078119 | 0.81 | LMNA (0.79) | NAMPTMEN1KMT2ARAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9079859-B2 | Synthetic lethal targeting of glucose transport | AUCKLAND UNISERVICES LIMITED (NZ) | 2015-07-14 | — | — | US | claimed |
| EP-2456435-B1 | HETEROARYL BENZAMIDES, COMPOSITIONS AND METHODS OF USE | UNIV LELAND STANFORD JUNIOR (US) | 2015-06-24 | — | — | EP | claimed |
| US-20140128397-A1 | SYNTHETIC LETHAL TARGETING OF GLUCOSE TRANSPORT | RUGA CORPORATION | 2014-05-08 | — | — | US | claimed |
| US-20120225862-A1 | HETEROARYL BENZAMIDES, COMPOSITIONS AND METHODS OF USE | AUCKLAND UNIVSERVICES LIMITED (NZ) | 2012-09-06 | — | — | US | claimed |
| US-11959096-B2 | Methods for selective inhibition of pluripotent stem cells | THE MEDICAL COLLEGE OF WISCONSIN, INC. (US) | 2024-04-16 | — | — | US | disclosed |
| US-20210017489-A1 | METHODS FOR SELECTIVE INHIBITION OF PLURIPOTENT STEM CELLS | THE MEDICAL COLLEGE OF WISCONSIN, INC. (US) | 2021-01-21 | — | — | US | disclosed |
| US-10808222-B2 | Methods for selective inhibition of pluripotent stem cells | THE MEDICAL COLLEGE OF WISCONSIN, INC. (US) | 2020-10-20 | — | — | US | disclosed |
| US-20190300847-A1 | METHODS FOR SELECTIVE INHIBITION OF PLURIPOTENT STEM CELLS | THE MEDICAL COLLEGE OF WISCONSIN, INC. | 2019-10-03 | — | — | US | disclosed |
| US-10316287-B2 | Methods for selective inhibition of pluripotent stem cells | THE MEDICAL COLLEGE OF WISCONSIN, INC. (US) | 2019-06-11 | — | — | US | disclosed |
| EP-3097186-B1 | METHODS FOR SELECTIVE INHIBITION OF PLURIPOTENT STEM CELLS | MEDICAL COLLEGE WISCONSIN INC (US) | 2019-05-08 | — | — | EP | disclosed |
| EP-3097186-A1 | METHODS FOR SELECTIVE INHIBITION OF PLURIPOTENT STEM CELLS | The Medical College of Wisconsin, Inc. (US) | 2016-11-30 | — | — | EP | disclosed |
| US-20160340642-A1 | METHODS FOR SELECTIVE INHIBITION OF PLURIPOTENT STEM CELLS | THE MEDICAL COLLEGE OF WISCONSIN, INC. | 2016-11-24 | — | — | US | disclosed |
| WO-2015112581-A1 | METHODS FOR SELECTIVE INHIBITION OF PLURIPOTENT STEM CELLS | THE MEDICAL COLLEGE OF WISCONSIN, INC. (US) | 2015-07-30 | — | — | WO | disclosed |
| US-9079859-B2 | Synthetic lethal targeting of glucose transport | AUCKLAND UNISERVICES LIMITED (NZ) | 2015-07-14 | — | — | US | disclosed |
| EP-2456435-B1 | HETEROARYL BENZAMIDES, COMPOSITIONS AND METHODS OF USE | UNIV LELAND STANFORD JUNIOR (US) | 2015-06-24 | — | — | EP | disclosed |
| US-20140128397-A1 | SYNTHETIC LETHAL TARGETING OF GLUCOSE TRANSPORT | RUGA CORPORATION | 2014-05-08 | — | — | US | disclosed |
| US-20120225862-A1 | HETEROARYL BENZAMIDES, COMPOSITIONS AND METHODS OF USE | AUCKLAND UNIVSERVICES LIMITED (NZ) | 2012-09-06 | — | — | US | disclosed |
| US-20120225862-A1 | HETEROARYL BENZAMIDES, COMPOSITIONS AND METHODS OF USE | AUCKLAND UNIVSERVICES LIMITED (NZ) | 2012-09-06 | — | — | US | disclosed |
| EP-2456435-A1 | HETEROARYL BENZAMIDES, COMPOSITIONS AND METHODS OF USE | The Board of Trustees of The Leland Stanford Junior University (US) | 2012-05-30 | — | — | EP | disclosed |
| WO-2011011514-A1 | HETEROARYL BENZAMIDES, COMPOSITIONS AND METHODS OF USE | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2011-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120225862-A1 | HETEROARYL BENZAMIDES, COMPOSITIONS AND METHODS OF USE | BRDT, NISCH, PAICS | NAMPT 624/4885MEN1 2511/4885KMT2A 502/4885 |
| US-20140128397-A1 | SYNTHETIC LETHAL TARGETING OF GLUCOSE TRANSPORT | SLC2A1, SLC2A3, SLC2A2 | NAMPT 601/4885MEN1 1974/4885KMT2A 1511/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.