Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | ADRB2 | P07550 | 6/20 | 0.57 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.57 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | MTOR | P42345 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30324664 | 1.00 | TSHR (0.58) | TSHRHIF1AMEN1CYP1A2KMT2A | |
| SCHEMBL2297678 | 0.86 | APAF1 (0.50) | TSHRHIF1AMEN1CYP1A2KMT2A | |
| SCHEMBL2299663 | 0.86 | APAF1 (0.50) | TSHRHIF1AMEN1CYP1A2KMT2A | |
| SCHEMBL2293722 | 0.86 | APAF1 (0.50) | TSHRHIF1AMEN1CYP1A2KMT2A | |
| SCHEMBL2297676 | 0.86 | APAF1 (0.50) | TSHRHIF1AMEN1CYP1A2KMT2A | |
| SCHEMBL12186585 | 0.86 | ADRB3 (0.51) | ADRB2ADRB1ADRB3 | |
| SCHEMBL2298355 | 0.86 | APAF1 (0.50) | TSHRHIF1AMEN1CYP1A2KMT2A | |
| SCHEMBL12186559 | 0.86 | ADRB3 (0.51) | ADRB2ADRB1ADRB3 | |
| SCHEMBL2293719 | 0.86 | APAF1 (0.50) | TSHRHIF1AMEN1CYP1A2KMT2A | |
| SCHEMBL16559373 | 0.84 | ADRB2 (0.48) | TSHRHIF1AMEN1CYP1A2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4861801-A | Treatment of depression by using a fluorophenacylamine derivative | Lafon, Laboratoire L. (FR) | 1989-08-29 | — | — | US | disclosed |
| US-4835315-A | Fluorophenacyl-amine derivatives and application thereof in therapeutics | LABORATOIRE L. LAFON (FR) | 1989-05-30 | — | — | US | disclosed |
| EP-0060954-B1 | DERIVATIVES OF FLUOROPHENACYL AMINES AND THEIR THERAPEUTIC USE | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1984-08-15 | — | — | EP | disclosed |
| EP-0060954-A1 | Derivatives of fluorophenacyl amines and their therapeutic use | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1982-09-29 | — | — | EP | disclosed |