Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.67 |
| ▸ | DRD2 | P14416 | 2/20 | 0.67 |
| ▸ | HTR2A | P28223 | 2/20 | 0.67 |
| ▸ | DRD3 | P35462 | 2/20 | 0.67 |
| ▸ | DRD1 | P21728 | 1/20 | 0.67 |
| ▸ | DRD5 | P21918 | 1/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | HRH1 | P35367 | 1/20 | 0.61 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.60 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.57 |
| ▸ | HTR7 | P34969 | 1/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10700125 | 1.00 | HTR1A (0.67) | HTR1ADRD2HTR2ADRD3DRD1 | |
| Hydrochloric Acid SCHEMBL10485627 | 0.98 | HTR1A (0.64) | HTR1ADRD2HTR2ADRD3DRD1 | |
| SCHEMBL10485746 | 0.94 | MEN1 (0.67) | HTR1ADRD2HTR2ADRD3DRD1 | |
| SCHEMBL10486189 | 0.94 | KCNH2 (0.70) | HTR1ADRD2HTR2ADRD3DRD1 | |
| Hydrochloric Acid SCHEMBL10486107 | 0.93 | MEN1 (0.69) | HTR1ADRD2HTR2ADRD3DRD1 | |
| Hydrochloric Acid SCHEMBL10485620 | 0.93 | KCNH2 (0.68) | HTR1ADRD2HTR2ADRD3DRD1 | |
| SCHEMBL10485663 | 0.88 | MEN1 (0.64) | MAPTKMT2AMEN1CACNA1GABCB1 | |
| SCHEMBL10486120 | 0.88 | MAPT (0.65) | HTR1AKCNH2MAPTKMT2AMEN1 | |
| SCHEMBL10485775 | 0.88 | MAPT (0.79) | HTR1ADRD2KCNH2MAPTKMT2A | |
| SCHEMBL10485969 | 0.88 | MEN1 (0.77) | HTR1AMAPTKMT2AMEN1CACNA1G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882330-A | 1-aryloxy-4-[((4-aryl)-1-piperazinyl]-2-butanols useful as antiallergy agents | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-11-21 | — | — | US | claimed |
| EP-0269383-A2 | 1-Aryloxy-4-[(4-aryl)-1-piperazinyl]-2-butanols useful as antiallergy agents | A.H. ROBINS COMPANY, INCORPORATED (US) | 1988-06-01 | — | — | EP | claimed |
| US-4882330-A | 1-aryloxy-4-[((4-aryl)-1-piperazinyl]-2-butanols useful as antiallergy agents | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-11-21 | — | — | US | disclosed |
| US-4806555-A | CARDIAC ARRHYTHMIA INHIBITOR | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-02-21 | — | — | US | disclosed |
| EP-0269383-A2 | 1-Aryloxy-4-[(4-aryl)-1-piperazinyl]-2-butanols useful as antiallergy agents | A.H. ROBINS COMPANY, INCORPORATED (US) | 1988-06-01 | — | — | EP | disclosed |