SCHEMBL10485751

SCHEMBL10485751

CCOc1ccc(C#Cc2ccc(C#N)cc2)cc1

nearest known ligand 0.58

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
NQO1 P15559 1/20 0.58
MAOB P27338 1/20 0.48
CYP2A6 P11509 1/20 0.48
TSHR P16473 1/20 0.48
TDP1 Q9NUW8 1/20 0.48
ACACB O00763 11/20 0.47
MAPT P10636 2/20 0.47
GAA P10253 1/20 0.47
ALDH1A1 P00352 1/20 0.47
LMNA P02545 1/20 0.46
TP53 P04637 1/20 0.46
LTA4H P09960 1/20 0.45
RAB9A P51151 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL509602 0.94 NQO1 (0.67) NQO1MAOBCYP2A6TSHRTDP1
Hydrochloric Acid SCHEMBL27878587 0.91 NQO1 (0.64) NQO1MAOBCYP2A6TSHRTDP1
SCHEMBL31160399 0.89 NQO1 (0.74) NQO1TSHRTDP1ACACBLTA4H
Alcohol SCHEMBL29171755 0.88 NQO1 (0.58) NQO1MAOBCYP2A6TSHRTDP1
SCHEMBL921673 0.88 LTA4H (0.61) NQO1MAOBCYP2A6TSHRTDP1
SCHEMBL8041598 0.88 NQO1 (0.58) NQO1MAOBCYP2A6TSHRMAPT
SCHEMBL12726667 0.88 NQO1 (0.58) NQO1MAOBCYP2A6TSHRMAPT
Ammonia Solution, Strong SCHEMBL3938785 0.84 NQO1 (0.54) NQO1MAOBCYP2A6TSHRTDP1
SCHEMBL27931308 0.84 CYP2A6 (0.55) NQO1MAOBCYP2A6TSHRTDP1
SCHEMBL11677967 0.82 GAA (0.56) NQO1TDP1MAPTGAAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4887889-A Organopolysiloxanes exhibiting nonlinear response HOECHST CELANESE CORPORATION (US) 1989-12-19 US disclosed
US-4855078-A Organopolysiloxanes exhibiting nonlinear response HOECHST CELANESE CORP. (US) 1989-08-08 US disclosed
US-4807968-A Polymer blends exhibiting nonlinear optical response HOECHST CELANESE CORP. (US) 1989-02-28 US disclosed
US-4801659-A Organopolysiloxanes exhibiting nonlinear optical response HOECHST CELANESE CORP. (US) 1989-01-31 US disclosed