SCHEMBL10486284

SCHEMBL10486284

Nc1nc(N)nc(-c2ccccc2OCBr)n1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 4/20 0.49
MAOB P27338 2/20 0.45
ALOX15 P16050 2/20 0.44
KDM4E B2RXH2 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
ADORA2A P29274 3/20 0.41
ADORA3 P0DMS8 2/20 0.41
ADORA2B P29275 2/20 0.41
ADORA1 P30542 2/20 0.41
POLB P06746 1/20 0.41
IKBKB O14920 1/20 0.41
BRAF P15056 1/20 0.41
NPC1 O15118 2/20 0.40
ALDH1A1 P00352 2/20 0.39
TSHR P16473 1/20 0.39
DHFR P00374 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2C9 P11712 1/20 0.39
HPGD P15428 1/20 0.39
CYP2C19 P33261 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9566491 0.83 DHFR (0.55) SMN1; SMN2MAOBALOX15KDM4EL3MBTL1
SCHEMBL9566443 0.80 BRD4 (0.57) SMN1; SMN2L3MBTL1DHFRMAPT
SCHEMBL9566557 0.79 CYP1A2 (0.56) SMN1; SMN2MAOBALDH1A1DHFRCYP1A2
SCHEMBL10486375 0.78 SMN1; SMN2 (0.44) SMN1; SMN2MAOBALOX15KDM4EL3MBTL1
SCHEMBL10486239 0.78 DHFR (0.44) SMN1; SMN2MAOBALOX15KDM4EL3MBTL1
SCHEMBL3678540 0.77 HSP90AA1 (0.58) SMN1; SMN2ALOX15KDM4EL3MBTL1ADORA2A
SCHEMBL10486182 0.76 SMN1; SMN2 (0.49) SMN1; SMN2MAOBALOX15KDM4EL3MBTL1
SCHEMBL17046876 0.74 SMN1; SMN2 (0.71) SMN1; SMN2ALOX15KDM4EL3MBTL1ADORA2A
SCHEMBL30468191 0.74 SMN1; SMN2 (0.71) SMN1; SMN2ALOX15KDM4EL3MBTL1ADORA2A
SCHEMBL9566555 0.72 SMN1; SMN2 (0.49) SMN1; SMN2ALOX15KDM4EL3MBTL1ADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4873242-A NOOTROPIC AGENTS NIPPON SHINYAKU CO., LTD. (JP) 1989-10-10 US claimed
US-4873242-A NOOTROPIC AGENTS NIPPON SHINYAKU CO., LTD. (JP) 1989-10-10 US disclosed