Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | CCR1 | P32246 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | CCR5 | P51681 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10982850 | 0.73 | DRD3 (0.58) | LMNACYP2D6TSHRPMP22DRD2 | |
| SCHEMBL30774207 | 0.71 | LMNA (0.60) | LMNAKDM4EGMNNTP53HSP90AA1 | |
| SCHEMBL28095840 | 0.71 | PLAU (0.47) | PLAUDRD2DRD3 | |
| SCHEMBL3310824 | 0.70 | PLAU (0.55) | MAPTNFKB1THPOHIF1APLAU | |
| SCHEMBL840914 | 0.70 | DRD2 (0.50) | PLAUDRD2DRD3 | |
| SCHEMBL17101631 | 0.69 | NR2E1 (0.60) | TP53PLAU | |
| Phenanthroline SCHEMBL15167899 | 0.68 | LMNA (0.61) | LMNAKDM4EGMNNTP53HSP90AA1 | |
| Phenanthroline SCHEMBL15167898 | 0.68 | LMNA (0.61) | LMNAKDM4EGMNNTP53HSP90AA1 | |
| Phenanthroline SCHEMBL27537097 | 0.68 | LMNA (0.61) | LMNAKDM4EGMNNTP53HSP90AA1 | |
| SCHEMBL5051400 | 0.67 | PLAU (0.55) | MAPTNFKB1THPOHIF1APLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4885373-A | AMINE DERVIVATIVES USED AS ANTIDEPRESSANT AND DOPAMINERGIC STIMULANTS | ADIR ET CIE (FR) | 1989-12-05 | — | — | US | disclosed |
| US-4874878-A | CHEMICAL INTERMEDIATES FOR ANTIDEPRESSANTS | ADIR ET CIE (FR) | 1989-10-17 | — | — | US | disclosed |
| US-4863951-A | ANTIDEPRESSANTS, ANTIAGRESSIVES, DOPAMINERGIC PROPERTIES | ADIR ET CIE (FR) | 1989-09-05 | — | — | US | disclosed |
| US-4851429-A | ANTIDEPRESSANT, TRANQUILIZERS | ADIR ET CIE (FR) | 1989-07-25 | — | — | US | disclosed |
| US-4521423-A | 7,8,9,10-Tetrahydrobenzo[h]quinolin-9-amine derivatives and compositions and methods for treating depression employing them | AYERST, MCKENNA & HARRISON, LTD. (CA) | 1985-06-04 | — | — | US | disclosed |
| US-4521423-A | 7,8,9,10-Tetrahydrobenzo[h]quinolin-9-amine derivatives and compositions and methods for treating depression employing them | AYERST, MCKENNA & HARRISON, LTD. (CA) | 1985-06-04 | — | — | US | disclosed |
| US-4521423-A | 7,8,9,10-Tetrahydrobenzo[h]quinolin-9-amine derivatives and compositions and methods for treating depression employing them | AYERST, MCKENNA & HARRISON, LTD. (CA) | 1985-06-04 | — | — | US | disclosed |