Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 20/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10715697 | 0.84 | AKR1B1 (0.66) | AKR1B1 | |
| SCHEMBL9858813 | 0.56 | MEN1 (0.38) | — | |
| SCHEMBL29225979 | 0.56 | CYP3A4 (0.61) | — | |
| SCHEMBL30933424 | 0.56 | CYP3A4 (0.61) | — | |
| SCHEMBL6283405 | 0.54 | KDM4E (0.54) | — | |
| SCHEMBL10778265 | 0.54 | PKM (0.36) | — | |
| SCHEMBL9858678 | 0.54 | MEN1 (0.49) | — | |
| SCHEMBL9818791 | 0.54 | PTGS2 (0.39) | — | |
| SCHEMBL6862119 | 0.54 | TSHR (0.44) | — | |
| SCHEMBL11785571 | 0.53 | KMT2A (0.41) | AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4853410-A | Hydroxyacetic acid derivatives for the treatment of diabetic complications | PFIZER INC. (US) | 1989-08-01 | — | — | US | disclosed |
| EP-0230379-A2 | Chroman- and thiochroman-4-acetic acids useful in the treatment of diabetic complications | PFIZER INC. (US) | 1987-07-29 | — | — | EP | disclosed |