Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.68 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10487607 | 0.98 | SMN1; SMN2 (0.67) | SMN1; SMN2HSD17B10SRD5A2TSHRCASP1 | |
| SCHEMBL10365113 | 0.82 | CNR2 (0.49) | SMN1; SMN2HSD17B10KMT2AMEN1POLB | |
| SCHEMBL11728744 | 0.81 | SMN1; SMN2 (1.00) | SMN1; SMN2HSD17B10SRD5A2TSHRCASP1 | |
| SCHEMBL10487806 | 0.77 | SMN1; SMN2 (0.62) | SMN1; SMN2HSD17B10SRD5A2TSHRCASP1 | |
| SCHEMBL9689290 | 0.77 | SMN1; SMN2 (0.66) | SMN1; SMN2HSD17B10SRD5A2TSHRCASP1 | |
| SCHEMBL9689174 | 0.76 | SMN1; SMN2 (0.64) | SMN1; SMN2HSD17B10SRD5A2TSHRCASP1 | |
| SCHEMBL9689264 | 0.76 | SMN1; SMN2 (0.64) | SMN1; SMN2HSD17B10SRD5A2TSHRCASP1 | |
| SCHEMBL10487745 | 0.76 | SMN1; SMN2 (0.60) | SMN1; SMN2HSD17B10SRD5A2MAPTKDM4E | |
| SCHEMBL30185351 | 0.75 | SMN1; SMN2 (0.71) | SMN1; SMN2HSD17B10SRD5A2TSHRCASP1 | |
| SCHEMBL195020 | 0.75 | SMN1; SMN2 (0.71) | SMN1; SMN2HSD17B10SRD5A2TSHRCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4883794-A | ANALGESICS, ANTICHOLINERGIC AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-11-28 | — | — | US | disclosed |
| EP-0308912-A2 | Pyrrolo(1,2-b)cinnolines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-03-29 | — | — | EP | disclosed |
| US-4800203-A | ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-01-24 | — | — | US | disclosed |