Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.66 |
| ▸ | CNR2 | P34972 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689264 | 0.88 | SMN1; SMN2 (0.64) | SMN1; SMN2HSD17B10CNR2ALDH1A1MAPK1 | |
| SCHEMBL9689174 | 0.88 | SMN1; SMN2 (0.64) | SMN1; SMN2HSD17B10CNR2ALDH1A1MAPK1 | |
| SCHEMBL10487740 | 0.80 | SMN1; SMN2 (0.58) | SMN1; SMN2HSD17B10CNR2ALDH1A1MEN1 | |
| SCHEMBL11728744 | 0.80 | SMN1; SMN2 (1.00) | SMN1; SMN2HSD17B10ALDH1A1MAPK1HIF1A | |
| SCHEMBL9689173 | 0.80 | SMN1; SMN2 (0.57) | SMN1; SMN2HSD17B10CNR2ALDH1A1MEN1 | |
| SCHEMBL10487745 | 0.79 | SMN1; SMN2 (0.60) | SMN1; SMN2HSD17B10CNR2ALDH1A1MAPK1 | |
| SCHEMBL9689142 | 0.79 | SMN1; SMN2 (0.56) | SMN1; SMN2HSD17B10CNR2ALDH1A1MAPK1 | |
| SCHEMBL9688875 | 0.77 | SMN1; SMN2 (0.54) | SMN1; SMN2HSD17B10CNR2ALDH1A1MEN1 | |
| SCHEMBL10487648 | 0.77 | SMN1; SMN2 (0.68) | SMN1; SMN2HSD17B10ALDH1A1MAPK1HIF1A | |
| Hydrochloric Acid SCHEMBL10487607 | 0.75 | SMN1; SMN2 (0.67) | SMN1; SMN2HSD17B10ALDH1A1MAPK1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0486807-A1 | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1992-05-27 | — | — | EP | disclosed |
| US-5082951-A | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (I) and intermediates therefor | SYNTEX (U.S.A.) INC. (US) | 1992-01-21 | — | — | US | disclosed |