Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.60 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10487913 | 0.90 | AKR1B1 (0.64) | AKR1B1AKR1A1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL10487906 | 0.90 | AKR1A1 (0.65) | AKR1B1AKR1A1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7860390 | 0.90 | AKR1B1 (0.76) | AKR1B1AKR1A1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL10487964 | 0.89 | AKR1A1 (0.46) | AKR1B1AKR1A1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL10487925 | 0.88 | AKR1B1 (0.61) | AKR1B1AKR1A1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL10487846 | 0.87 | AKR1B1 (0.57) | AKR1B1AKR1A1ALDH1A1MEN1KMT2A | |
| SCHEMBL10487834 | 0.86 | AKR1B1 (0.79) | AKR1B1AKR1A1MEN1KMT2AMAPT | |
| SCHEMBL10487923 | 0.86 | AKR1B1 (0.59) | AKR1B1AKR1A1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL9046143 | 0.86 | AKR1A1 (0.59) | AKR1B1AKR1A1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL10487889 | 0.85 | AKR1B1 (0.52) | AKR1B1AKR1A1ALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4883800-A | DIABETES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-11-28 | — | — | US | disclosed |
| US-4734419-A | Quinazoline derivatives, compositions thereof and their use in treating diabetic complications | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-29 | — | — | US | disclosed |
| EP-0218999-A2 | New quinazoline derivatives, process for their production and pharmaceutical compositions comprising them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-04-22 | — | — | EP | disclosed |