Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1A1 | P14550 | 1/20 | 0.65 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PARG | Q86W56 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9046143 | 0.96 | AKR1A1 (0.59) | AKR1A1AKR1B1ALDH1A1SMN1; SMN2PPARG | |
| SCHEMBL7860390 | 0.93 | AKR1B1 (0.76) | AKR1A1AKR1B1ALDH1A1SMN1; SMN2PPARG | |
| SCHEMBL10487808 | 0.90 | AKR1B1 (0.60) | AKR1A1AKR1B1ALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL9046869 | 0.89 | AKR1B1 (0.53) | AKR1A1AKR1B1ALDH1A1SMN1; SMN2PPARG | |
| SCHEMBL10488005 | 0.88 | AKR1A1 (0.52) | AKR1A1AKR1B1ALDH1A1POLBMEN1 | |
| SCHEMBL10487846 | 0.88 | AKR1B1 (0.57) | AKR1A1AKR1B1ALDH1A1NPSR1TSHR | |
| SCHEMBL10487913 | 0.88 | AKR1B1 (0.64) | AKR1A1AKR1B1ALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL10488007 | 0.86 | AKR1B1 (0.85) | AKR1A1AKR1B1MEN1KMT2A | |
| SCHEMBL10487855 | 0.86 | AKR1A1 (0.55) | AKR1A1AKR1B1ALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL10487925 | 0.85 | AKR1B1 (0.61) | AKR1A1AKR1B1ALDH1A1SMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4883800-A | DIABETES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-11-28 | — | — | US | disclosed |
| US-4734419-A | Quinazoline derivatives, compositions thereof and their use in treating diabetic complications | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-29 | — | — | US | disclosed |
| EP-0218999-A2 | New quinazoline derivatives, process for their production and pharmaceutical compositions comprising them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-04-22 | — | — | EP | disclosed |