Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.54 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.53 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10487936 | 0.90 | TRAP1 (0.55) | ALDH1A1HPGDKDM4ESMN1; SMN2HSP90AA1 | |
| SCHEMBL10487983 | 0.86 | TRAP1 (0.52) | ALDH1A1HPGDKDM4ESMN1; SMN2HSP90AA1 | |
| SCHEMBL7752011 | 0.84 | AKR1A1 (0.58) | ALDH1A1HSP90AA1TRAP1HSP90B1OPRM1 | |
| SCHEMBL10487924 | 0.84 | TRAP1 (0.53) | ALDH1A1HPGDKDM4ESMN1; SMN2HSP90AA1 | |
| SCHEMBL10488205 | 0.82 | TRAP1 (0.59) | ALDH1A1SMN1; SMN2HSP90AA1TRAP1HSP90B1 | |
| SCHEMBL10487908 | 0.82 | DDR1 (0.58) | HSP90AA1TRAP1HSP90B1DDR1 | |
| SCHEMBL10487998 | 0.81 | TRAP1 (0.47) | ALDH1A1HPGDKDM4ESMN1; SMN2HSP90AA1 | |
| SCHEMBL10488017 | 0.79 | TRAP1 (0.51) | ALDH1A1KDM4ESMN1; SMN2HSP90AA1TRAP1 | |
| Acetic Acid SCHEMBL4363267 | 0.79 | AKR1B1 (0.60) | HPGDKDM4EHSP90AA1TRAP1HSP90B1 | |
| SCHEMBL7101724 | 0.76 | KMT2A (0.78) | ALDH1A1HPGDKDM4ESMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4883800-A | DIABETES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-11-28 | — | — | US | disclosed |
| US-4734419-A | Quinazoline derivatives, compositions thereof and their use in treating diabetic complications | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-29 | — | — | US | disclosed |
| EP-0218999-A2 | New quinazoline derivatives, process for their production and pharmaceutical compositions comprising them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-04-22 | — | — | EP | disclosed |