Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 6/20 | 0.74 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.74 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10487930 | 0.92 | AKR1B1 (0.65) | AKR1B1AKR1A1TP53MAPTMEN1 | |
| SCHEMBL10487878 | 0.90 | AKR1B1 (0.86) | AKR1B1AKR1A1HDAC1HDAC8HDAC6 | |
| SCHEMBL10487843 | 0.89 | AKR1A1 (0.58) | AKR1B1AKR1A1HDAC1HDAC8HDAC6 | |
| SCHEMBL9319101 | 0.87 | AKR1B1 (0.81) | AKR1B1AKR1A1HDAC1HDAC8HDAC6 | |
| Zenarestat SCHEMBL48959 | 0.85 | AKR1B1 (1.00) | AKR1B1AKR1A1HDAC1HDAC8HDAC6 | |
| Zenarestat SCHEMBL30583313 | 0.85 | AKR1B1 (1.00) | AKR1B1AKR1A1HDAC1HDAC8HDAC6 | |
| Zenarestat SCHEMBL29688249 | 0.85 | AKR1B1 (1.00) | AKR1B1AKR1A1HDAC1HDAC8HDAC6 | |
| SCHEMBL10487869 | 0.85 | AKR1B1 (0.78) | AKR1B1AKR1A1HDAC1HDAC8HDAC6 | |
| SCHEMBL10487918 | 0.83 | AKR1B1 (0.76) | AKR1B1AKR1A1HDAC1HDAC8HDAC6 | |
| SCHEMBL10487848 | 0.83 | AKR1B1 (0.75) | AKR1B1AKR1A1HDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4883800-A | DIABETES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-11-28 | — | — | US | disclosed |
| US-4734419-A | Quinazoline derivatives, compositions thereof and their use in treating diabetic complications | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-29 | — | — | US | disclosed |
| EP-0218999-A2 | New quinazoline derivatives, process for their production and pharmaceutical compositions comprising them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-04-22 | — | — | EP | disclosed |