SCHEMBL10488359

SCHEMBL10488359

O=Cc1c(Cl)ccc2c(Cl)c3ccccc3cc12

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 5/20 0.44
ALDH1A1 P00352 3/20 0.42
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
ERN1 O75460 3/20 0.39
SLC2A1 P11166 2/20 0.38
HIF1A Q16665 2/20 0.35
HSD17B10 Q99714 2/20 0.35
CYP1B1 Q16678 2/20 0.35
ESR1 P03372 1/20 0.35
ESR2 Q92731 1/20 0.35
CYP1A2 P05177 5/20 0.34
PADI4 Q9UM07 1/20 0.34
MAPT P10636 2/20 0.33
CYP2C9 P11712 2/20 0.33
CYP2C19 P33261 2/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
GMNN O75496 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10348681 0.81 ERN1 (0.42) CYP2A6ALDH1A1MEN1KMT2ATDP1
SCHEMBL3694889 0.81 ALDH1A1 (0.47) CYP2A6ALDH1A1MEN1KMT2ATDP1
SCHEMBL3697087 0.79 ALDH1A1 (0.45) CYP2A6ALDH1A1MEN1KMT2ATDP1
SCHEMBL3777795 0.79 ALDH1A1 (0.45) CYP2A6ALDH1A1MEN1KMT2ATDP1
SCHEMBL1246034 0.78 ERN1 (0.60) CYP2A6ALDH1A1MEN1KMT2ATDP1
SCHEMBL3707056 0.77 HPRT1 (0.52) CYP2A6ALDH1A1MEN1KMT2ATDP1
SCHEMBL3767140 0.77 HPRT1 (0.52) CYP2A6ALDH1A1MEN1KMT2ATDP1
SCHEMBL10488197 0.76 MEN1 (0.41) CYP2A6ALDH1A1MEN1KMT2ATDP1
SCHEMBL10348702 0.76 ERN1 (0.55) CYP2A6ALDH1A1MEN1KMT2ATDP1
SCHEMBL27289193 0.75 ERN1 (0.52) CYP2A6ALDH1A1MEN1KMT2ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4803226-A ANTITUMOR AGENTS BURROUGHS WELLCOME CO. (US) 1989-02-07 US disclosed
US-4803221-A Anthracene derivatives BURROUGHS WELLCOME CO. (US) 1989-02-07 US disclosed
US-4719047-A ANTITUMOR BURROUGHS WELLCOME CO. (US) 1988-01-12 US disclosed
US-4719049-A ANTITUMOR BURROUGHS WELLCOME CO. (US) 1988-01-12 US disclosed
EP-0125702-B1 POLYCYCLIC AROMATIC COMPOUNDS THE WELLCOME FOUNDATION LIMITED (GB) 1987-08-12 EP disclosed
EP-0125702-A2 Polycyclic aromatic compounds THE WELLCOME FOUNDATION LIMITED (GB) 1984-11-21 EP disclosed