SCHEMBL10488442

SCHEMBL10488442

CCc1ccc2c(CNC(C)(CO)CO)c3ccccc3cc2c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.41
CYP2A6 P11509 1/20 0.41
KMT2A Q03164 3/20 0.39
NPBWR1 P48145 1/20 0.39
MCHR1 Q99705 1/20 0.39
SLC2A1 P11166 1/20 0.36
GAA P10253 1/20 0.36
KIF11 P52732 1/20 0.35
HTR2A P28223 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
ALDH1A1 P00352 2/20 0.34
KDM4E B2RXH2 1/20 0.34
MEN1 O00255 1/20 0.34
TSHR P16473 1/20 0.34
HSD17B10 Q99714 1/20 0.34
CD274 Q9NZQ7 1/20 0.33
HPGD P15428 1/20 0.33
SIGMAR1 Q99720 3/20 0.32
HTR6 P50406 1/20 0.32
AKR1B1 P15121 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10488343 0.92 KMT2A (0.44) CYP1A2CYP2A6KMT2ANPBWR1MCHR1
SCHEMBL10488406 0.88 HTR2A (0.43) CYP1A2KMT2ANPBWR1MCHR1SLC2A1
Hydrochloric Acid SCHEMBL10488372 0.86 KMT2A (0.43) CYP1A2KMT2ANPBWR1MCHR1SLC2A1
SCHEMBL10348808 0.85 KMT2A (0.40) CYP1A2KMT2ANPBWR1MCHR1SLC2A1
SCHEMBL10488578 0.83 KMT2A (0.45) CYP1A2CYP2A6KMT2ANPBWR1MCHR1
Hydrochloric Acid SCHEMBL10686453 0.82 KMT2A (0.47) CYP1A2CYP2A6KMT2ANPBWR1MCHR1
SCHEMBL10348864 0.80 KMT2A (0.41) CYP1A2CYP2A6KMT2ANPBWR1MCHR1
SCHEMBL10546894 0.80 MAPK1 (0.42) CYP1A2KMT2ANPBWR1MCHR1SLC2A1
SCHEMBL10488510 0.80 HTR2A (0.39) CYP1A2KMT2ANPBWR1MCHR1SLC2A1
SCHEMBL10348690 0.80 SLC2A1 (0.48) KMT2ANPBWR1MCHR1SLC2A1HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0125702-B1 POLYCYCLIC AROMATIC COMPOUNDS THE WELLCOME FOUNDATION LIMITED (GB) 1987-08-12 EP claimed
US-4803221-A Anthracene derivatives BURROUGHS WELLCOME CO. (US) 1989-02-07 US disclosed
US-4719049-A ANTITUMOR BURROUGHS WELLCOME CO. (US) 1988-01-12 US disclosed
EP-0125702-B1 POLYCYCLIC AROMATIC COMPOUNDS THE WELLCOME FOUNDATION LIMITED (GB) 1987-08-12 EP disclosed
EP-0125702-A2 Polycyclic aromatic compounds THE WELLCOME FOUNDATION LIMITED (GB) 1984-11-21 EP disclosed