SCHEMBL10488463

SCHEMBL10488463

N#Cc1ccccc1OCC(O)CNCCN

nearest known ligand 0.64

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ADRB1 P08588 17/20 0.64
ADRB2 P07550 2/20 0.64
ADRB3 P13945 2/20 0.64
KDM4E B2RXH2 1/20 0.64
MEN1 O00255 1/20 0.64
CYP1A2 P05177 1/20 0.64
ALOX15 P16050 1/20 0.64
KMT2A Q03164 1/20 0.64
HTR1A P08908 1/20 0.63
ADRA2A P08913 1/20 0.63
ADRA2B P18089 1/20 0.63
MAOA P21397 1/20 0.63
HTR2B P41595 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10887933 0.93 ADRB1 (0.59) ADRB1ADRB2ADRB3KDM4EMEN1
SCHEMBL11792446 0.92 ADRB1 (0.66) ADRB1ADRB2ADRB3KDM4EMEN1
SCHEMBL11794422 0.92 ADRB1 (0.66) ADRB1ADRB2ADRB3KDM4EMEN1
SCHEMBL11803062 0.92 ADRB1 (0.72) ADRB1ADRB2ADRB3KDM4EMEN1
SCHEMBL11790103 0.91 ADRB1 (0.65) ADRB1ADRB2ADRB3KDM4EMEN1
SCHEMBL11798041 0.91 ADRB1 (0.65) ADRB1ADRB2ADRB3KDM4EMEN1
SCHEMBL11954116 0.87 HTR1A (0.64) ADRB1ADRB2ADRB3KDM4EMEN1
SCHEMBL10653746 0.87 ADRB1 (0.64) ADRB1ADRB2ADRB3KDM4EMEN1
SCHEMBL7363467 0.85 ADRB1 (0.62) ADRB1ADRB2ADRB3KDM4EMEN1
SCHEMBL14155430 0.84 ADRB1 (0.66) ADRB1ADRB2ADRB3KDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4873254-A ADRENERGIC BLOCKING AGENTS OR CALCIUM CHANNEL BLOCKERS; HYPOTENSIVE AGENTS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1989-10-10 US disclosed
US-4863949-A CARDIOVASCULAR DISORDER TREATMENT BOEHRINGER MANNHEIM GMBH (DE) 1989-09-05 US disclosed
EP-0194751-A1 Dihydropyridine alkanol amines, process for their preparation and pharmaceutical compositions containing them IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1986-09-17 EP disclosed
US-4419363-A ADRENERGIC BLOCKING AGENTS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1983-12-06 US disclosed
US-4387099-A Alkanolamine derivatives IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1983-06-07 US disclosed
US-4346111-A CARDIOVASCULAR DISORDERS, HYPOTENSIVE AGENTS, ADRENERGIC BLOCKING AGENTS IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1982-08-24 US disclosed
US-4327113-A DRUGS FOR TREATMENT OF HEART DISEASES, ADRENERGIC BLOCKING AGENTS, ETC IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1982-04-27 US disclosed
US-4318921-A HYPOTENSIVE AGENTS; ADRENERGIC BLOCKING AGENTS IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1982-03-09 US disclosed
US-4260632-A ADRENERGIC BLOCKING AGENTS, CARDIOVASCULAR DISORDERS IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1981-04-07 US disclosed
US-4221807-A ADRENERGIC BLOCKING AGENTS IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1980-09-09 US disclosed
US-4219561-A ADRENERGIC BLOCKING AGENTS, HYPOTENSIVE, ANTIARRHYTHMIA, ANGINA PECTORIS IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1980-08-26 US disclosed
US-4211878-A ADRENERGIC BLOCKING AGENTS IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1980-07-08 US disclosed
US-4171374-A 1-ARYLOXY-3-SUBSTITUTED UREIDO-ALKYLAMINO-2-PROPANOLS, ADRENERGIC BLOCKING AGENTS, CARDIAC STIMULANTS IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1979-10-16 US disclosed
US-4167581-A 1-ARYLOXY-3-(ACYLAMINO)ALKYLAMINO-2-PROPANOL ADRENERGIC BLOCKING, AGENTS AND CARDIAC STIMULANTS IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1979-09-11 US disclosed
US-4141987-A HYPOTENSIVE, ADRENERGIC BLOCKING AGENT IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1979-02-27 US disclosed