Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.35 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10488456 | 0.81 | SMN1; SMN2 (0.50) | SMN1; SMN2PDE4DHCAR2LMNAL3MBTL1 | |
| SCHEMBL10488584 | 0.80 | HCAR3 (0.48) | SMN1; SMN2PDE4DHCAR3LRRK2HCAR2 | |
| SCHEMBL10488470 | 0.78 | SMN1; SMN2 (0.48) | SMN1; SMN2PDE4DHCAR3HCAR2LMNA | |
| SCHEMBL10488646 | 0.76 | SMN1; SMN2 (0.46) | SMN1; SMN2PDE4DHCAR3HCAR2LMNA | |
| SCHEMBL10488490 | 0.75 | SMN1; SMN2 (0.45) | SMN1; SMN2PDE4DHCAR3HCAR2LMNA | |
| SCHEMBL10488484 | 0.74 | LRRK2 (0.41) | SMN1; SMN2PDE4DHCAR3LRRK2HCAR2 | |
| SCHEMBL10488819 | 0.73 | SMN1; SMN2 (0.46) | SMN1; SMN2PDE4DHCAR3HCAR2LMNA | |
| SCHEMBL10488515 | 0.72 | HCAR2 (0.41) | SMN1; SMN2PDE4DHCAR2LMNAL3MBTL1 | |
| SCHEMBL10488645 | 0.72 | SMN1; SMN2 (0.73) | SMN1; SMN2HCAR2LMNAAURKAMAPK1 | |
| SCHEMBL11084510 | 0.72 | SMN1; SMN2 (0.48) | SMN1; SMN2PDE4DLMNAMAPTAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4871737-A | 3-Amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants muscle relaxants and anxiolytics | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-10-03 | — | — | US | disclosed |
| EP-0315433-A2 | 3-amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants, muscle relaxants and anxiolytics | A.H. ROBINS COMPANY, INCORPORATED (US) | 1989-05-10 | — | — | EP | disclosed |
| US-4826866-A | 3-amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants, muscle relaxants and anxiolytics | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-05-02 | — | — | US | disclosed |