Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | PTGES | O14684 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | FADS1 | O60427 | 4/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10488775 | 0.85 | SMN1; SMN2 (0.70) | SMN1; SMN2ALOX5MAPTPOLBHPGD | |
| SCHEMBL10488620 | 0.84 | SMN1; SMN2 (0.54) | SMN1; SMN2MAPTALDH1A1KDM4EPOLB | |
| SCHEMBL10488935 | 0.84 | EGFR (0.54) | SMN1; SMN2HPGDFADS1MAPK1 | |
| SCHEMBL10488603 | 0.84 | POLB (0.55) | SMN1; SMN2MAPTALDH1A1POLBHPGD | |
| SCHEMBL10488958 | 0.82 | SMN1; SMN2 (0.59) | SMN1; SMN2MAPTKDM4EPOLBPDE4D | |
| SCHEMBL10488475 | 0.81 | POLB (0.55) | SMN1; SMN2MAPTALDH1A1POLBHPGD | |
| SCHEMBL10488614 | 0.79 | SMN1; SMN2 (0.56) | SMN1; SMN2MAPTPOLBPDE4DMAPK1 | |
| SCHEMBL10488579 | 0.79 | MAPT (0.66) | SMN1; SMN2MAPTALDH1A1POLBPDE4D | |
| SCHEMBL10488746 | 0.78 | SMN1; SMN2 (0.60) | SMN1; SMN2MAPTKDM4EPOLBPDE4D | |
| SCHEMBL10488676 | 0.76 | MAPT (0.69) | SMN1; SMN2MAPTALDH1A1POLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0315433-A2 | 3-amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants, muscle relaxants and anxiolytics | A.H. ROBINS COMPANY, INCORPORATED (US) | 1989-05-10 | — | — | EP | claimed |
| US-4826866-A | 3-amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants, muscle relaxants and anxiolytics | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-05-02 | — | — | US | claimed |
| EP-0315433-A2 | 3-amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants, muscle relaxants and anxiolytics | A.H. ROBINS COMPANY, INCORPORATED (US) | 1989-05-10 | — | — | EP | disclosed |