Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SMO | Q99835 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10488589 | 0.87 | SMN1; SMN2 (0.55) | LMNAALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL10488467 | 0.84 | TTR (0.50) | LMNAALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL20438319 | 0.79 | MEN1 (0.55) | LMNAALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL10488580 | 0.77 | HTT (0.50) | ALDH1A1MAPTHTTHPGD | |
| SCHEMBL10488632 | 0.76 | HTT (0.53) | ALDH1A1SMN1; SMN2KDM4EMAPTHTT | |
| SCHEMBL10488586 | 0.74 | LRRK2 (0.47) | LMNAALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL13720391 | 0.72 | ALDH1A1 (0.60) | LMNAALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL9778508 | 0.71 | ALDH1A1 (0.59) | LMNAALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL7235226 | 0.71 | HTR3E (0.61) | LMNAALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL27911478 | 0.71 | ALDH1A1 (0.47) | LMNAALDH1A1KDM4EDRD4POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4871737-A | 3-Amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants muscle relaxants and anxiolytics | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-10-03 | — | — | US | disclosed |
| US-4826866-A | 3-amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants, muscle relaxants and anxiolytics | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-05-02 | — | — | US | disclosed |