Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 3/20 | 0.47 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10488475 | 0.88 | POLB (0.55) | MAPTPOLBSMN1; SMN2LMNAMEN1 | |
| SCHEMBL10488676 | 0.85 | MAPT (0.69) | MAPTPOLBSMN1; SMN2LMNAKMT2A | |
| SCHEMBL10488556 | 0.83 | KMT2A (0.59) | MAPTPOLBSMN1; SMN2LMNAMEN1 | |
| SCHEMBL10488603 | 0.81 | POLB (0.55) | MAPTPOLBSMN1; SMN2LMNAMEN1 | |
| SCHEMBL10488832 | 0.79 | MAPT (0.61) | MAPTPOLBSMN1; SMN2LMNAKMT2A | |
| SCHEMBL7263569 | 0.79 | MAPT (0.56) | MAPTPOLBSMN1; SMN2LMNAKMT2A | |
| SCHEMBL10488579 | 0.78 | MAPT (0.66) | MAPTPOLBSMN1; SMN2LMNAMEN1 | |
| SCHEMBL10488501 | 0.78 | POLB (0.66) | MAPTPOLBSMN1; SMN2LMNAKMT2A | |
| SCHEMBL10488654 | 0.77 | MAPT (0.78) | MAPTPOLBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL10488775 | 0.77 | SMN1; SMN2 (0.70) | MAPTPOLBSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0315433-A2 | 3-amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants, muscle relaxants and anxiolytics | A.H. ROBINS COMPANY, INCORPORATED (US) | 1989-05-10 | — | — | EP | claimed |
| US-4826866-A | 3-amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants, muscle relaxants and anxiolytics | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-05-02 | — | — | US | claimed |