Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8654580 | 0.87 | HTT (0.51) | HTTKDM4ELMNAALOX15TSHR | |
| SCHEMBL10489654 | 0.85 | ALDH1A1 (0.57) | NPC1RAB9ATRPM4KDM4ELMNA | |
| SCHEMBL10489955 | 0.82 | LMNA (0.56) | NPC1RAB9ATRPM4KDM4ELMNA | |
| SCHEMBL10489837 | 0.81 | NPC1 (0.76) | NPC1RAB9ATRPM4KDM4EL3MBTL1 | |
| SCHEMBL10490004 | 0.81 | KDM4E (0.56) | HTTNPC1RAB9ATRPM4KDM4E | |
| SCHEMBL20302610 | 0.78 | ALDH1A1 (0.54) | HTTNPC1RAB9AKDM4ELMNA | |
| SCHEMBL8656262 | 0.78 | ALDH1A1 (0.51) | HTTKDM4ELMNAALOX15TSHR | |
| SCHEMBL8652584 | 0.76 | PLK1 (0.43) | HTTNPC1RAB9AKDM4ELMNA | |
| SCHEMBL10489664 | 0.76 | ALDH1A1 (0.50) | HTTNPC1RAB9ALMNANLRP3 | |
| SCHEMBL8657531 | 0.75 | ALDH1A1 (0.56) | NPC1RAB9AKDM4ELMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4873232-A | ARTHRITIS AND AUTOIMMUNE DISEASES | SYNTEX (US) | 1989-10-10 | — | — | US | claimed |
| US-4873232-A | ARTHRITIS AND AUTOIMMUNE DISEASES | SYNTEX (US) | 1989-10-10 | — | — | US | disclosed |