Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GALR2 | O43603 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | CCR6 | P51684 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10489743 | 0.90 | SMN1; SMN2 (0.51) | AKR1B1ALDH1A1KMT2ASMN1; SMN2CYP1A2 | |
| SCHEMBL10489810 | 0.88 | AKR1B1 (0.52) | AKR1B1ALDH1A1KMT2ASMN1; SMN2CYP1A2 | |
| SCHEMBL10489903 | 0.86 | NPC1 (0.49) | AKR1B1ALDH1A1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL10662510 | 0.81 | NPC1 (0.49) | AKR1B1ALDH1A1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL10657842 | 0.81 | SMN1; SMN2 (0.52) | AKR1B1ALDH1A1KMT2ASMN1; SMN2CYP1A2 | |
| SCHEMBL10489728 | 0.78 | SMN1; SMN2 (0.65) | AKR1B1ALDH1A1KMT2ASMN1; SMN2CYP1A2 | |
| SCHEMBL10489699 | 0.77 | TDP1 (0.39) | AKR1B1ALDH1A1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL11086324 | 0.76 | KMT2A (0.76) | ALDH1A1KMT2ASMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL10489777 | 0.76 | ALDH1A1 (0.39) | AKR1B1ALDH1A1SMN1; SMN2MAPTPOLB | |
| SCHEMBL10364446 | 0.75 | SMN1; SMN2 (0.46) | AKR1B1ALDH1A1KMT2ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4873232-A | ARTHRITIS AND AUTOIMMUNE DISEASES | SYNTEX (US) | 1989-10-10 | — | — | US | disclosed |
| US-4745116-A | INHIBITORS OF SERINE PROTEASE | SYNTEX (U.S.A.) INC. (US) | 1988-05-17 | — | — | US | disclosed |
| US-4665070-A | SERINE PROTEINASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1987-05-12 | — | — | US | disclosed |
| EP-0206323-A1 | 2-Oxy-4H-3,1-benzoxazin-4-one derivatives and related compounds | SYNTEX (U.S.A.) INC. (US) | 1986-12-30 | — | — | EP | disclosed |